ArticlePediatric cardiology2013
Multi-tiered analysis of brain injury in neonates with congenital heart disease.
Article in Pediatric cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Paediatric brain MRI findings following congenital heart surgery: a systematic review.Archives of disease in childhood · 2022Pooled it
- The brain protective effect of dexmedetomidine during surgery for paediatric patients with congenital heart disease.The Journal of international medical research · 2019Trial
- Genetics and Brain Health in Adults With Congenital Heart Disease: A Consensus Statement From the ACHD/Neuro 2024 Conference.Journal of the American Heart Association · 2026Article
- Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease.Journal of clinical medicine · 2024Article
- Continuous electroencephalography (cEEG) in infants with congenital heart disease (CHD).Pediatric research · 2023Article
- Preterm congenital heart disease and neurodevelopment: the importance of looking beyond the initial hospitalization.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration.Stroke · 2022Article
- In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury.Pediatric research · 2022Article
- Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery.Antioxidants (Basel, Switzerland) · 2022Article
- MRI studies of brain size and growth in individuals with congenital heart disease.Translational pediatrics · 2021Review
- Hypothermia for cardiogenic encephalopathy in neonates with dextro-transposition of the great arteries.Interactive cardiovascular and thoracic surgery · 2021Article
- Heart rate variability is depressed in the early transitional period for newborns with complex congenital heart disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- School-Age Test Proficiency and Special Education After Congenital Heart Disease Surgery in Infancy.The Journal of pediatrics · 2016Article
- A Novel TBX1 Loss-of-Function Mutation Associated with Congenital Heart Disease.Pediatric cardiology · 2015Article
- Amplitude-integrated EEG in newborns with critical congenital heart disease predicts preoperative brain magnetic resonance imaging findings.Pediatric neurology · 2015Article
- Congenital cardiac anomalies and white matter injury.Trends in neurosciences · 2015Review
- A novel NKX2.6 mutation associated with congenital ventricular septal defect.Pediatric cardiology · 2015Article
- PITX2 Loss-of-Function Mutation Contributes to Congenital Endocardial Cushion Defect and Axenfeld-Rieger Syndrome.PloS one · 2015Article
- White matter injury in newborns with congenital heart disease: a diffusion tensor imaging study.Pediatric neurology · 2014Observational
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Early brain injury occurs in newborns with congenital heart disease (CHD) placing them at risk for impaired neurodevelopmental outcomes. Predictors for preoperative brain injury have not been well described in CHD newborns. This study aimed to analyze, retrospectively, brain magnetic resonance imaging (MRI) in a heterogeneous group of newborns who had CHD surgery during the first month of life using a detailed qualitative CHD MRI Injury Score, quantitative imaging assessments (regional apparent diffusion coefficient [ADC] values and brain volumes), and clinical characteristics. Seventy-three newborns who had CHD surgery at 8 ± 5 (mean ± SD) days of life and preoperative brain MRI were included; 38 also had postoperative MRI. Thirty-four (34 of 73, 47 %) had at least one type of preoperative brain injury, and 28 of 38 (74 %) had postoperative brain injury. The 5-min APGAR score was negatively associated with preoperative injury, but there was no difference between CHD types. Infants with intraparenchymal hemorrhage, deep gray matter injury, and/or watershed infarcts had the highest CHD MRI Injury Scores. ADC values and brain volumes were not different in infants with different CHD types or in those with and without brain injury. In a mixed group of CHD newborns, brain injury was found preoperatively on MRI in almost 50 %, and there were no significant baseline characteristic differences to predict this early brain injury except 5-min APGAR score. We conclude that all infants, regardless of CHD type, who require early surgery should be evaluated with MRI because they are all at high risk for brain injury.
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Registered trials
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