ArticleTranslational psychiatry2013
Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Computational biological analysis reveals that HIF-1 and FoxO signaling pathways influence cognitive impairment in patients with depression.Translational psychiatry · 2025Article
- An Updated Bio-Behavioral Profile of the Flinders Sensitive Line Rat: Reviewing the Findings of the Past Decade.Pharmacology research & perspectives · 2025Review
- HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides.EMBO molecular medicine · 2023Article
- Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression.Life (Basel, Switzerland) · 2023Review
- Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders.Frontiers in neural circuits · 2022Review
- The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression.Scientific reports · 2021Article
- The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders.Molecular psychiatry · 2018Article
- Neuropeptide Y in Alcohol Addiction and Affective Disorders.Frontiers in endocrinology · 2017Review
- The role of neuropeptide-Y in nandrolone decanoate-induced attenuation of antidepressant effect of exercise.PloS one · 2017Article
- MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.The international journal of neuropsychopharmacology · 2016Article
- Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression.Translational psychiatry · 2016Article
- Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function.Environmental epigenetics · 2016Review
- The Role of Neuropeptide Y mRNA Expression Level in Distinguishing Different Types of Depression.Frontiers in aging neuroscience · 2016Article
- Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium.The international journal of neuropsychopharmacology · 2015Article
- Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.PloS one · 2015Article
- Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.The international journal of neuropsychopharmacology · 2014Article
- Metabolic disturbances connecting obesity and depression.Frontiers in neuroscience · 2013Review
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptide Y (NPY) has been implicated in depression, emotional processing and stress response. Part of this evidence originates from human single-nucleotide polymorphism (SNP) studies. In the present study, we report that a SNP in the rat Npy promoter (C/T; rs105431668) affects in vitro transcription and DNA-protein interactions. Genotyping studies showed that the C-allele of rs105431668 is present in a genetic rat model of depression (Flinders sensitive line; FSL), while the SNP's T-allele is present in its controls (Flinders resistant line; FRL). In vivo experiments revealed binding of a transcription factor (CREB2) and a histone acetyltransferase (Ep300) only at the SNP locus of the FRL. Accordingly, the FRL had increased hippocampal levels of Npy mRNA and H3K18 acetylation; a gene-activating histone modification maintained by Ep300. Next, based on previous studies showing antidepressant-like effects of physical activity in the FSL, we hypothesized that physical activity may affect Npy's epigenetic status. In line with this assumption, physical activity was associated with increased levels of Npy mRNA and H3K18 acetylation. Physical activity was also associated with reduced mRNA levels of a histone deacetylase (Hdac5). Conclusively, the rat rs105431668 appears to be a functional Npy SNP that may underlie depression-like characteristics. In addition, the achieved epigenetic reprogramming of Npy provides molecular support for the putative effectiveness of physical activity as a non-pharmacological antidepressant.
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