Trial reportEuropean radiology2013
Diagnostic accuracy of unenhanced, contrast-enhanced perfusion and angiographic MRI sequences for pulmonary embolism diagnosis: results of independent sequence readings.
Trial report in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02059551 (Diagnostic Performances of Magnetic Resonance Imaging Combined With Venous Ultrasonography of the Legs for Pulmonary Embolism), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Performances of Magnetic Resonance Imaging Combined With Venous Ultrasonography of the Legs for Pulmonary Embolism
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Comparison between CT and MRI in the assessment of pulmonary embolism: A meta-analysis.Medicine · 2017Pooled it
- Role of pulmonary perfusion magnetic resonance imaging for the diagnosis of pulmonary hypertension: A review.World journal of radiology · 2023Review
- Diagnostic accuracy of true fast imaging with steady-state precession, MR pulmonary angiography and volume-interpolated body examination for pulmonary embolism compared with CT pulmonary angiography.Experimental and therapeutic medicine · 2021Article
- Management of Venous Thromboembolisms: Part II. The Consensus for Pulmonary Embolism and Updates.Acta Cardiologica Sinica · 2020Review
- Clinical Value of Noncontrast-Enhanced Radial Quiescent-Interval Slice-Selective (QISS) Magnetic Resonance Angiography for the Diagnosis of Acute Pulmonary Embolism Compared to Contrast-Enhanced Computed Tomography and Cartesian Balanced Steady-State Free Precession.Journal of magnetic resonance imaging : JMRI · 2020Article
- Multimodal indirect imaging signs of pulmonary embolism.The British journal of radiology · 2020Article
- Diagnostic performance of contrast-enhanced and unenhanced combined pulmonary artery MRI and magnetic resonance venography techniques in the diagnosis of venous thromboembolism.The British journal of radiology · 2019Article
- Primary diagnosis of pulmonary embolism with unenhanced MRI for patients not eligible for CTPA: Clinical outcome.European journal of radiology open · 2019Article
- Diffusion-weighted imaging in acute pulmonary embolism: a feasibility study.Acta radiologica open · 2018Article
- Differentiation of antemortem pulmonary thromboembolism and postmortem clot with unenhanced MRI: a case report.Forensic science, medicine, and pathology · 2018Article
- "Pulmonary Vein Sign" for Pulmonary Embolism Diagnosis in Computed Tomography Angiography.Lung · 2017Article
- How to train radiology residents to diagnose pulmonary embolism using a dedicated MRI protocol.Acta radiologica open · 2017Article
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo independently evaluate unenhanced, contrast-enhanced perfusion and angiographic MR sequences for pulmonary embolism (PE) diagnosis.
methodsProspective investigation, including 274 patients who underwent perfusion, unenhanced 2D steady-state-free-precession (SSFP) and contrast-enhanced 3D angiographic MR sequences on a 1.5-T unit, in addition to CTA (CT angiography). Two independent readers evaluated each sequence independently in random order. Sensitivity, specificity, predictive values and inter-reader agreement were calculated for each sequence, excluding sequences judged inconclusive. Sensitivity was also calculated according to PE location.
resultsContrast-enhanced angiographic sequences showed the highest sensitivity (82.9 and 89.7 %, reader 1 and reader 2, respectively), specificity (98.5 and 100 %) and agreement (kappa value 0.77). Unenhanced angiographic sequences, although less sensitive overall (68.7 and 76.4 %), were sensitive for the detection of proximal PE (92.7 and 100 %) and showed high specificity (96.1 and 99.1 %) and good agreement (kappa value 0.62). Perfusion sequences showed lower sensitivity (75.0 and 79.3 %), specificity (84.8 and 89.7 %) and agreement (kappa value 0.51), and a negative predictive value of 84.8 % at best.
conclusionsCompared with contrast-enhanced angiographic sequences, unenhanced sequences demonstrate lower sensitivity, except for proximal PE, but high specificity and agreement. The negative predictive value of perfusion sequences was insufficient to safely rule out PE. KEY POINTS: • Unenhanced angiographic MR sequences are very specific and can identify proximal PE. • Contrast-enhanced MR angiographic sequences show high sensitivity for PE diagnosis. • A normal MR perfusion result does not exclude PE. • Inter-reader agreement is better for angiographic than perfusion MR sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.