ReviewThe Journal of physiology2013
Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?
Review in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- T-tubular remodeling occurs in a cardiomyocyte-autonomous manner following pathological mechanical stiffness exposure.Journal of molecular and cellular cardiology plus · 2026Article
- Regional Differences in CaInternational journal of molecular sciences · 2023Article
- Article
- The Physiology and Pathophysiology of T-Tubules in the Heart.Frontiers in physiology · 2021Review
- Transverse tubular network structures in the genesis of intracellular calcium alternans and triggered activity in cardiac cells.Journal of molecular and cellular cardiology · 2018Article
- Dyadic Plasticity in Cardiomyocytes.Frontiers in physiology · 2018Review
- Interplay Between Sub-Cellular Alterations of Calcium Release and T-Tubular Defects in Cardiac Diseases.Frontiers in physiology · 2018Article
- Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.Progress in biophysics and molecular biology · 2017Article
- Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy.Current heart failure reports · 2017Review
- High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.Journal of biophotonics · 2016Article
- Altered Na/Ca exchange distribution in ventricular myocytes from failing hearts.American journal of physiology. Heart and circulatory physiology · 2016Article
- Heterogeneity of T-Tubules in Pig Hearts.PloS one · 2016Article
- T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling.Journal of molecular and cellular cardiology · 2015Article
- Functional cardiac imaging by random access microscopy.Frontiers in physiology · 2014Article
- Arrhythmia: 100 years on from George Ralph Mines.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The transverse (t-) tubules of mammalian ventricular myocytes are invaginations of the surface membrane. The function of many of the key proteins involved in excitation-contraction coupling is located predominantly at the t-tubules, which thus form a Ca(2+)-handling micro-environment that is central to the normal rapid activation and relaxation of the ventricular myocyte. Although cellular arrhythmogenesis shares many ion flux pathways with normal excitation-contraction coupling, the role of the t-tubules in such arrhythmogenesis has not previously been considered. In this brief review we consider how the location and co-location of proteins at the t-tubules may contribute to the generation of arrhythmogenic delayed and early afterdepolarisations, and how the loss of t-tubules that occurs during heart failure may alter the generation of such arrhythmias, as well as contributing to other types of arrhythmia as a result of changes of electrical heterogeneity within the whole heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.