ReviewThe Journal of physiology2013
Muscle glycogen stores and fatigue.
Review in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 5 syntheses or guidelines pooled it, 341 citations in OpenAlex.
- Effects of Low-Carbohydrate and Ketogenic Diets on Anaerobic Performance in Competitive Athletes: A Systematic Review and Meta-Analysis.Nutrients · 2026Pooled it
- Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis.Physiological reports · 2025Pooled it
- Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review.Cells · 2024Pooled it
- The Effect of Carbohydrate Intake on Strength and Resistance Training Performance: A Systematic Review.Nutrients · 2022Pooled it
- Pooled it
- Low carbohydrate availability reduces power output at the moderate-to-heavy transition, impairs efficiency, and increases median power frequency during cycling in females.European journal of applied physiology · 2026Trial
- Oral post-exercise garlic extract supplementation enhances glycogen replenishment but does not up-regulate mitochondria biogenesis mRNA expression in human-exercised skeletal muscle.Journal of the International Society of Sports Nutrition · 2024Trial
- Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-blinded crossover clinical trial.Journal of the International Society of Sports Nutrition · 2023Trial
- The Effect of Vinegar Supplementation on High-Intensity Cycling Performance within Recreationally Trained Individuals.Medicina (Kaunas, Lithuania) · 2020Trial
- Acute Maltodextrin Supplementation During Resistance Exercise.Journal of sports science & medicine · 2020Trial
- Anaerobic Performance after a Low-Carbohydrate Diet (LCD) Followed by 7 Days of Carbohydrate Loading in Male Basketball Players.Nutrients · 2019Trial
- Chronic βThe Journal of physiology · 2018Trial
- Glucose but not fructose ingestion improves endurance cycling performance despite similar neuromuscular fatigue at exhaustion.European journal of applied physiology · 2026Article
- Hitting the Wall in Marathon Running: An Integrative Psychophysiological and Durability-Based Review.Journal of functional morphology and kinesiology · 2026Review
- The Role of Nutrition in Exercise and Sports.Nutrients · 2026Article
- Sex Differences in Durability Following Heavy Intensity Cycling Exercise in Trained Athletes.Scandinavian journal of medicine & science in sports · 2026Article
- Task Failure in Endurance Sports: A Review.Sports medicine (Auckland, N.Z.) · 2026Review
- Low-dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice.The Journal of physiology · 2026Article
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.Endocrine reviews · 2026Review
- Probiotic Lactobacillus rhamnosus GKLC1 enhances endurance and metabolism in mice with low exercise capacity.BMC research notes · 2026Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies performed at the beginning of the last century revealed the importance of carbohydrate as a fuel during exercise, and the importance of muscle glycogen on performance has subsequently been confirmed in numerous studies. However, the link between glycogen depletion and impaired muscle function during fatigue is not well understood and a direct cause-and-effect relationship between glycogen and muscle function remains to be established. The use of electron microscopy has revealed that glycogen is not homogeneously distributed in skeletal muscle fibres, but rather localized in distinct pools. Furthermore, each glycogen granule has its own metabolic machinery with glycolytic enzymes and regulating proteins. One pool of such glycogenolytic complexes is localized within the myofibrils in close contact with key proteins involved in the excitation-contraction coupling and Ca2+ release from the sarcoplasmic reticulum (SR). We and others have provided experimental evidence in favour of a direct role of decreased glycogen, localized within the myofibrils, for the reduction in SR Ca2+ release during fatigue. This is consistent with compartmentalized energy turnover and distinctly localized glycogen pools being of key importance for SR Ca2+ release and thereby affecting muscle contractility and fatigability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.