ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Additive association of vitamin D insufficiency and sarcopenia with low femoral bone mineral density in noninstitutionalized elderly population: the Korea National Health and Nutrition Examination Surveys 2009-2010.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Global and regional prevalence of osteopenia in chronic kidney disease: a systematic review and meta-analysis.Clinical and experimental medicine · 2025Pooled it
- Global epidemiological features and impact of osteosarcopenia: A comprehensive meta-analysis and systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Pooled it
- Micronutrient status among women in the midlife in selected Asian regions: a scoping review.Frontiers in global women's health · 2026Review
- Low Serum 25-Hydroxyvitamin D as a Risk Factor for Frailty in Community-Dwelling Older Men: A Korean Nationwide Study.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- DASH diet as a preventive strategy for sarcopenia: integrated observational and mendelian randomization analyses in US adults.Nutrition & metabolism · 2025Article
- Does an Association among Sarcopenia and Metabolic Risk Factors Exist in People Older Than 65 Years? A Systematic Review and Meta-Analysis of Observational Studies.Life (Basel, Switzerland) · 2023Review
- Vitamin D Deficiency in Older Patients-Problems of Sarcopenia, Drug Interactions, Management in Deficiency.Nutrients · 2021Review
- Prevalence and temporal trends of presarcopenia metrics and related body composition measurements from the 1999 to 2006 NHANES.BMJ open · 2020Article
- Effect of Osteosarcopenia on Postoperative Functional Outcomes and Subsequent Fracture in Elderly Hip Fracture Patients.Geriatric orthopaedic surgery & rehabilitation · 2020Article
- Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function.Journal of cachexia, sarcopenia and muscle · 2019Article
- Associations between Sarcopenia and Metabolic Risk Factors: A Systematic Review and Meta-Analysis.Journal of obesity & metabolic syndrome · 2018Article
- Comparison and Validation of 10 Equations Including a Novel Method for Estimation of LDL-cholesterol in a 168,212 Asian Population.Medicine · 2016Article
- The role of sarcopenia in the risk of osteoporotic hip fracture.Clinical rheumatology · 2015Review
- Therapies for musculoskeletal disease: can we treat two birds with one stone?Current osteoporosis reports · 2014Review
- Serum cholesterol concentration and prevalence, awareness, treatment, and control of high low-density lipoprotein cholesterol in the Korea National Health and Nutrition Examination Surveys 2008-2010: Beyond the Tip of the Iceberg.Journal of the American Heart Association · 2014Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledVitamin D insufficiency and sarcopenia are crucial risk factors for osteoporosis. In a study of noninstitutionalized elderly subjects, we investigated the simultaneous effect of vitamin D and sarcopenia on bone mineral density (BMD) and found that sarcopenia was associated with low BMD in the femur, especially in those with suboptimal vitamin D levels.
introductionAlthough vitamin D insufficiency and sarcopenia are prevalent in the elderly population worldwide, their possible influence on BMD has not been determined. We aimed to investigate the different effect of vitamin D insufficiency and sarcopenia on BMD in the elderly Korean population.
methodsIndividuals aged 60 or older were selected from those who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Surveys conducted in 2009 and 2010; 1,596 males and 1,886 females were analyzed. Appendicular skeletal muscle mass (ASM) and BMD were assessed by dual-energy X-ray absorptiometry; serum 25-hydroxyvitamin D [25(OH)D] and a panel of clinical and laboratory parameters were also measured.
resultsThe study population was divided into four groups according to their vitamin D and sarcopenic status. BMD in total femur and in the femoral neck but not the lumbar spine was markedly decreased in sarcopenic subjects with vitamin D insufficiency [25(OH)D < 20 ng/ml] comparing to other groups, regardless of gender. Multivariable linear regression models showed that BMD was significantly associated with ASM and high daily calcium intake as well as conventional risk factors such as age, body mass index (BMI), and history of fracture. Independent predictors for low femur BMD included sarcopenia, low daily calcium intake, low 25(OH)D levels, age, and BMI.
conclusionsThese data showed that an association between vitamin D insufficiency and low BMD was more prominent in elderly subjects with sarcopenia.
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