ArticleClinical oral investigations2014
Effects of enamel matrix proteins in combination with a bovine-derived natural bone mineral for the repair of bone defects.
Article in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Amelogenin-Derived Peptides in Bone Regeneration: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis.Clinical oral investigations · 2015Pooled it
- Evaluation of bone regeneration in rat calvaria using combination of enamel matrix derivate and bone graft substitute: a histological, histometric and immunohistochemical study.Oral and maxillofacial surgery · 2025Article
- Bony Defect Regeneration in Periodontitis: A Systematic Review of the Literature Regarding the Use of Enamel Matrix Derivative Proteins.Dentistry journal · 2025Review
- The Potential of Enamel Matrix Derivative in Countering Bisphosphonate-Induced Effects in Osteoblasts.Life (Basel, Switzerland) · 2024Article
- Influence of Occlusal Hypofunction on Alveolar Bone Healing in Rats.International journal of molecular sciences · 2023Article
- Healing of Experimental Periodontal Defects Following Treatment with Fibroblast Growth Factor-2 and Deproteinized Bovine Bone Mineral.Biomolecules · 2021Article
- Regeneration of the Periodontal Apparatus in Aggressive Periodontitis Patients.Dentistry journal · 2019Review
- [Neuropeptide Y Y1 receptor antagonist PD160170 promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro and femoral defect repair in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Comparison of Different Periodontal Healing of Critical Size Noncontained and Contained Intrabony Defects in Beagles.Chinese medical journal · 2017Article
- Synthesis and characterization of CaO-loaded electrospun matrices for bone tissue engineering.Clinical oral investigations · 2016Article
- Osteoinductive potential of 4 commonly employed bone grafts.Clinical oral investigations · 2016Article
- Combined treatment with parathyroid hormone (1-34) and beta-tricalcium phosphate had an additive effect on local bone formation in a rat defect model.Medical & biological engineering & computing · 2016Article
- Bone grafting material in combination with Osteogain for bone repair: a rat histomorphometric study.Clinical oral investigations · 2016Article
- Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis.Clinical oral investigations · 2016Article
- Effect of bone graft density on in vitro cell behavior with enamel matrix derivative.Clinical oral investigations · 2015Article
- Enhanced Healing of Rat Calvarial Bone Defects with Hypoxic Conditioned Medium from Mesenchymal Stem Cells through Increased Endogenous Stem Cell Migration via Regulation of ICAM-1 Targeted-microRNA-221.Molecules and cells · 2015Article
- In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold.International journal of nanomedicine · 2015Article
- A comparative study of Sr-incorporated mesoporous bioactive glass scaffolds for regeneration of osteopenic bone defects.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPreviously, the use of enamel matrix derivative (EMD) in combination with a natural bone mineral (NBM) was able to stimulate periodontal ligament cell and osteoblast proliferation and differentiation. Despite widespread use of EMD for periodontal applications, the effects of EMD on bone regeneration are not well understood. The aim of the present study was to test the ability of EMD on bone regeneration in a rat femur defect model in combination with NBM. MATERIALS AND
methodsTwenty-seven rats were treated with either NBM or NBM + EMD and assigned to histological analysis at 2, 4, and 8 weeks. Defect morphology and mineralized bone were assessed by μCT. For descriptive histology, hematoxylin and eosin staining and Safranin O staining were performed.
resultsSignificantly more newly formed trabecular bone was observed at 4 weeks around the NBM particles precoated with EMD when compared with NBM particles alone. The drilled control group, in contrast, achieved minimal bone regeneration at all three time points (P < 0.05).
conclusionsThe present results may suggest that EMD has the ability to enhance the speed of new bone formation when combined with NBM particles in rat osseous defects. CLINICAL RELEVANCE: These findings may provide additional clinical support for the combination of EMD with bone graft for the repair of osseous and periodontal intrabony defects.
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