ArticleBritish journal of cancer2013
Myofibroblast activation in colorectal cancer lymph node metastases.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Association of future cancer metastases with fibroblast activation protein-α: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer.EBioMedicine · 2015Trial
- Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer.Molecular biomedicine · 2025Article
- Cancer-Associated Fibroblast Heterogeneity and Its Influence on the Extracellular Matrix and the Tumor Microenvironment.International journal of molecular sciences · 2023Review
- Article
- Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals distinct cancer-associated fibroblasts in head and neck squamous cell carcinoma.Annals of translational medicine · 2021Article
- Article
- The inflammation-nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection.Surgery today · 2020Article
- Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer.Cancer immunology, immunotherapy : CII · 2019Article
- Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer.Oncotarget · 2018Article
- Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression.Scientific reports · 2017Article
- Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer.Oncotarget · 2017Article
- Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer.Clinical medicine insights. Pathology · 2017Article
- Myofibroblast distribution is associated with invasive growth types of colorectal cancer.Oncology reports · 2016Article
- Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer.Oncology reports · 2016Article
- Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.Cell and tissue research · 2016Article
- Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells.Cell cycle (Georgetown, Tex.) · 2016Article
- Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- P4H9-detected molecule expression on spindle-shaped fibroblasts indicates malignant phenotype of colorectal cancer.British journal of cancer · 2015Article
- The lymph node pre-metastatic niche.Journal of molecular medicine (Berlin, Germany) · 2015Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMyofibroblasts have an important role in regulating the normal colorectal stem cell niche. While the activation of myofibroblasts in primary colorectal cancers has been previously described, myofibroblast activation in lymph node metastases has not been described before.
methodsParaffin-embedded lymph node sections from patients with macrometastases, micrometastases and isolated tumour cells were stained to identify myofibroblasts and to characterise the distribution of different cell types in tumour-containing lymph nodes. The extent of myofibroblast presence was quantified and compared with the size of the metastasis and degree of proliferation and differentiation of the cancer cells.
resultsWe show substantial activation of myofibroblasts in the presence of colorectal metastases in lymph nodes, which is intimately associated with glandular structures, both in micro- and macrometastases. The degree of activation is positively associated with the size of the metastases and the proportion of Ki67+ve cancer cells, and negatively associated with the degree of enterocyte differentiation as measured by CK20 expression.
conclusionThe substantial activation of myofibroblasts in tumour-containing lymph nodes strongly suggests that these metastatic cancer cells are still significantly dependent on their microenvironment. Further understanding of these epithelial-mesenchymal interactions could lead to the development of new therapies in metastatic disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.