ArticleJournal of chemical neuroanatomy2013
Coordinate regulation of noradrenergic and serotonergic brain regions by amygdalar neurons.
Article in Journal of chemical neuroanatomy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Learned helplessness and learned controllability: from neurobiology to cognitive, emotional and behavioral neurosciences.Frontiers in psychiatry · 2025Review
- Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat.The journal of physiological sciences : JPS · 2024Article
- Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder.IBRO neuroscience reports · 2021Review
- Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Serotonin release in the central nucleus of the amygdala in response to noxious and innocuous cutaneous stimulation in anesthetized rats.The journal of physiological sciences : JPS · 2016Article
- Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress.Brain structure & function · 2015Article
- Knockdown of corticotropin-releasing factor in the central amygdala reverses persistent viscerosomatic hyperalgesia.Translational psychiatry · 2015Article
- Chronic alcohol exposure differentially affects activation of female locus coeruleus neurons and the subcellular distribution of corticotropin releasing factor receptors.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry.Brain structure & function · 2015Article
- The integrative role of the sigh in psychology, physiology, pathology, and neurobiology.Progress in brain research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Based on the importance of the locus coeruleus-norepinephrine (LC-NE) system and the dorsal raphe nucleus-serotonergic (DRN-5-HT) system in stress-related pathologies, additional understanding of brain regions coordinating their activity is of particular interest. One such candidate is the amygdalar complex, and specifically, the central nucleus (CeA), which has been implicated in emotional arousal and is known to send monosynaptic afferent projections to both these regions. Our present data using dual retrograde tract tracing is the first to demonstrate a population of amygdalar neurons that project in a collateralized manner to the LC and DRN, indicating that amygdalar neurons are positioned to coordinately regulate the LC and DRN, and links these brain regions by virtue of a common set of afferents. Further, we have also characterized the phenotype of a population of these collaterally projecting neurons from the amygdala as containing corticotropin releasing factor or dynorphin, two peptides heavily implicated in the stress response. Understanding the co-regulatory influences of this limbic region on 5HT and NE regions may help fill a gap in our knowledge regarding neural circuits impacting these systems and their adaptations in stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.