ArticleGenetic testing and molecular biomarkers2013
Prolactin receptor gene polymorphisms are associated with gestational diabetes.
Article in Genetic testing and molecular biomarkers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Human Placental Lactogen in Relation to Maternal Metabolic Health and Fetal Outcomes: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Prolactin in relation to gestational diabetes and metabolic risk in pregnancy and postpartum: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2.Nutrients · 2025Review
- Gestational diabetes mellitus - more than the eye can see - a warning sign for future maternal health with transgenerational impact.Frontiers in clinical diabetes and healthcare · 2025Review
- Fetal sex effects on maternal health can now be tested via randomization: A first-in-class illustration in cows on glucoregulatory outcomes.Theriogenology · 2024Article
- Human placental lactogen (human chorionic somatomammotropin) and oxytocin during pregnancy: Individual patterns and associations with maternal-fetal attachment, anxiety, and depression.Hormones and behavior · 2024Article
- Article
- The prolactin receptor (Genes & diseases · 2024Article
- Insulin Sensitivity and β-Cell Function During Early and Late Pregnancy in Women With and Without Gestational Diabetes Mellitus.Diabetes care · 2023Article
- Beta-cell compensation and gestational diabetes.The Journal of biological chemistry · 2023Review
- The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome.Journal of ovarian research · 2023Article
- Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study.European journal of medical research · 2023Article
- O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes.Placenta · 2023Article
- Exogenous Lactogenic Signaling Stimulates Beta Cell Replication In Vivo and In Vitro.Biomolecules · 2022Article
- The interplay between prolactin and cardiovascular disease.Frontiers in endocrinology · 2022Review
- Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse.Development (Cambridge, England) · 2022Article
- Severe Hyperprolactinemia Promotes Brown Adipose Tissue Whitening and Aggravates High Fat Diet Induced Metabolic Imbalance.Frontiers in endocrinology · 2022Article
- Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex.International journal of molecular sciences · 2021Review
- Nutrition as Prevention Factor of Gestational Diabetes Mellitus: A Narrative Review.Nutrients · 2021Review
- Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aimsHuman placental lactogen (hPL) acts via the prolactin receptor (PRLR) on maternal β-cells to mediate increases in β-cell mass and function during normal pregnancy. This interaction between hPL and PRLR is essential to maintain normal glucose homeostasis and to address the increased metabolic demands of pregnancy. Given the importance of the PRLR-hPL axis in pancreatic islet cell adaptation to pregnancy, we hypothesized that genetic variation in the PRLR gene could influence risk of development of gestational diabetes mellitus (GDM). DNA samples from 96 mothers affected by GDM and 96 unaffected cases were genotyped for 8 selected single nucleotide polymorphisms (SNPs) in PRLR.
resultsSignificant associations were identified in two SNPs analyzed. The minor alleles of PRLR SNPs rs10068521 and rs9292578 were more frequently observed in GDM cases than controls and were associated with a 2.36-fold increased risk for GDM in those carrying the minor allele.
conclusionSNPs of the PRLR gene 5' UTR and promoter region are associated with increased risk for GDM in a population of Chilean subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.