ReviewThe European journal of neuroscience2013
Sleep: a synchrony of cell activity-driven small network states.
Review in The European journal of neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.Nature communications · 2023Pooled it
- Association between habitual sleep duration and Alzheimer's disease: A cross-sectional study based on NHANES 2007-2018.Medicine · 2026Article
- Local sleep in songbirds: different simultaneous sleep states across the avian pallium.Journal of sleep research · 2025Article
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations.Frontiers in neuroscience · 2025Article
- Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus.Nature neuroscience · 2023Article
- Tripping on the edge of consciousness.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Working around the Clock: Is a Person's Endogenous Circadian Timing for Optimal Neurobehavioral Functioning Inherently Task-Dependent?Clocks & sleep · 2022Article
- The hypothalamic link between arousal and sleep homeostasis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Role of sleep deprivation in immune-related disease risk and outcomes.Communications biology · 2021Review
- Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HTNeuroscience bulletin · 2020Article
- Sleep and circadian rhythms: Evolutionary entanglement and local regulation.Neurobiology of sleep and circadian rhythms · 2020Article
- Sleep- and time of day-linked RNA transcript expression in wild-type and IL1 receptor accessory protein-null mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Sleep deprivation, vigilant attention, and brain function: a review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices.Frontiers in systems neuroscience · 2020Review
- Article
- Interleukin-1 receptor accessory proteins are required for normal homeostatic responses to sleep deprivation.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Article
- Local sleep.Sleep medicine reviews · 2019Review
- Exploring phylogeny to find the function of sleep.Nature reviews. Neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We posit a bottom-up sleep-regulatory paradigm in which state changes are initiated within small networks as a consequence of local cell activity. Bottom-up regulatory mechanisms are prevalent throughout nature, occurring in vastly different systems and levels of organization. Synchronization of state without top-down regulation is a fundamental property of large collections of small semi-autonomous entities. We posit that such synchronization mechanisms are sufficient and necessary for whole-organism sleep onset. Within the brain we posit that small networks of highly interconnected neurons and glia, for example cortical columns, are semi-autonomous units oscillating between sleep-like and wake-like states. We review evidence showing that cells, small networks and regional areas of the brain share sleep-like properties with whole-animal sleep. A testable hypothesis focused on how sleep is initiated within local networks is presented. We posit that the release of cell activity-dependent molecules, such as ATP and nitric oxide, into the extracellular space initiates state changes within the local networks where they are produced. We review mechanisms of ATP induction of sleep-regulatory substances and their actions on receptor trafficking. Finally, we provide an example of how such local metabolic and state changes provide mechanistic explanations for clinical conditions, such as insomnia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.