ArticleFEBS open bio2012
Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism.
Article in FEBS open bio, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Metabolomics Profiling and AKR Characterization During Paurometabolous Development of Corythucha ciliata (Hemiptera: Tingidae).Journal of insect science (Online) · 2019Article
- A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival ofThe Journal of biological chemistry · 2017Article
- Methods for studying the metabolic basis of Drosophila development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Metabolomic Studies inGenetics · 2017Review
- Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens.G3 (Bethesda, Md.) · 2016Article
- Entometabolomics: applications of modern analytical techniques to insect studies.Entomologia experimentalis et applicata · 2015Review
- A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output.Metabolites · 2015Article
- Methods for studying metabolism in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis.G3 (Bethesda, Md.) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine being much higher in y. In addition, lysine acetate was elevated, and the levels of methyl lysines were lower, in y than in OR.
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