Evidence map›Paper›PMID 23650563›Full record

ArticlePloS one2013

Predatory bacteria: a potential ally against multidrug-resistant Gram-negative pathogens.

Daniel E Kadouri, Kevin To, Robert M Q Shanks, Yohei Doi

Abstract read
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed.

  1. Review
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  10. Bacteria vs bacteria; the future of antibiotics?New microbes and new infections · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Predatory Bacteria can ReducebioRxiv : the preprint server for biology · 2023
    Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel E KadouriDepartment of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America. kadourde@umdnj.edu
Kevin To
Robert M Q Shanks
Yohei Doi

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann · 1989 to 2026
$17.8M
Novel virulence and exoenzyme regulatorsR01AI085570 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHANKS, ROBERT M · 2010 to 2014
$1.8M
Multidrug-Resistant Acinetobacter baumanniiK22AI080584 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2009 to 2010
$269k
NEI NIH HHS EY08098NEI NIH HHS P30 EY008098NIAID NIH HHS AI085570NIAID NIH HHS K22 AI080584NIAID NIH HHS K22AI080584NIAID NIH HHS R01 AI085570
6 · The paper itself

Abstract

Multidrug-resistant (MDR) Gram-negative bacteria have emerged as a serious threat to human and animal health. Bdellovibrio spp. and Micavibrio spp. are Gram-negative bacteria that prey on other Gram-negative bacteria. In this study, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on MDR Gram-negative clinical strains was examined. Although the potential use of predatory bacteria to attack MDR pathogens has been suggested, the data supporting these claims is lacking. By conducting predation experiments we have established that predatory bacteria have the capacity to attack clinical strains of a variety of ß-lactamase-producing, MDR Gram-negative bacteria. Our observations indicate that predatory bacteria maintained their ability to prey on MDR bacteria regardless of their antimicrobial resistance, hence, might be used as therapeutic agents where other antimicrobial drugs fail.

Indexed as

Acinetobacter baumanniiAlphaproteobacteriaAntibiosisBdellovibrioDisk Diffusion Antimicrobial TestsDrug Resistance, Multiple, BacterialEscherichia coliKlebsiella pneumoniaeMicrobial ViabilityPseudomonas

Identifiers

PMID23650563
PMCPMC3641118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.