ArticlePloS one2013
Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- From Antigenic Drive to Clonal Autonomy: An Update on Molecular Mechanisms of HCV-Related B-Cell Lymphomagenesis.Cancers · 2026Review
- Renal Involvement in Mixed Cryoglobulinemic Vasculitis: Current Perspectives.Journal of clinical medicine · 2025Review
- Carcinogenic mechanisms of virus-associated lymphoma.Frontiers in immunology · 2024Review
- Hepatitis C Virus (HCV)-Ribonucleic Acid (RNA) As a Biomarker for Lymphoid Malignancy with HCV Infection.Cancers · 2023Review
- Article
- Pathogenic mechanism of miR-21 in autoimmune lymphoid hyperplasia syndrome.Oncology letters · 2017Article
- Proof-of-concept study: profile of circulating microRNAs in Bovine serum harvested during acute and persistent FMDV infection.Virology journal · 2017Article
- The impact of chronic hepatitis C infection on cholesterol metabolism in PBMCs is associated with microRNA-146a expression.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- New insights into HCV-related rheumatologic disorders: A review.Journal of advanced research · 2017Review
- The roles of microRNA families in hepatic fibrosis.Cell & bioscience · 2017Review
- Cryoglobulin Test and Cryoglobulinemia Hepatitis C-Virus Related.Mediterranean journal of hematology and infectious diseases · 2017Review
- HCV-induced miR146a controls SOCS1/STAT3 and cytokine expression in monocytes to promote regulatory T-cell development.Journal of viral hepatitis · 2016Article
- Hepatitis C Therapy in Renal Patients: Who, How, When?Infectious diseases and therapy · 2016Review
- The expanding spectrum of HCV-related cryoglobulinemic vasculitis: a narrative review.Clinical and experimental medicine · 2016Review
- Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies.Hepatology international · 2015Article
- MicroRNA expression in hepatitis C virus-related malignancies: A brief review.World journal of gastroenterology · 2015Review
- B cell non-Hodgkin's lymphoma in chronic hepatitis C virus patients: An interesting relationship.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Complex interactions between microRNAs and hepatitis B/C viruses.World journal of gastroenterology · 2014Review
- Relevance of miR-21 in HIV and non-HIV-related lymphomas.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- MicroRNA and hepatitis C virus--challenges in investigation and translation: a review of the literature.Diagnostic microbiology and infectious disease · 2014Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus infection is closely related to lymphoproliferative disorders (LPDs), including mixed cryoglobulinemia (MC) and some lymphomas. Modification of the expression of specific microRNAs (miRNAs) has been associated with different autoimmune diseases and/or LPDs. No data exist about the modifications in miRNA expression in HCV-associated LPDs. The aim of this study was to analyze the expression levels of a panel of miRNAs previously associated with autoimmune/LPDs in a large population of HCV patients with and without MC or non-Hodgkin's lymphoma (NHL), to identify potential markers of evolution of HCV infection. PBMC expression of miR-Let-7d, miR-16, miR-21, miR-26b, miR-146a and miR-155 was evaluated by real-time PCR in 167 HCV patients (75 with MC [MC-HCV], 11 with HCV-associated NHL [NHL-HCV], 81 without LPD [HCV]) and in 35 healthy subjects (HS). A significant increase in miR-21 (p<0.001), miR-16 (p<0.01) and miR-155 (p<0.01) expression was detected in PBMCs from only NHL patients whereas a significant decrease in miR-26b was detected in both MC and NHL subjects (p<0.01) when compared to HS and HCV groups. A restoration of miR-26b levels was observed in the post-treatment PBMCs of 35 HCV-MC patients experiencing complete virological and clinical response following antiviral therapy. This study, for the first time, shows that specific microRNAs in PBMC from HCV patients who developed MC and/or NHL are modulated differently. The specific, reversible downregulation of miR-26b strongly suggests the key role it plays in the pathogenesis of HCV-related LPDs and its usefulness as a biomarker of the evolution of HCV infection to these disorders.
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