ArticlePloS one2013
Mycobacterium tuberculosis infection is associated with the development of erythema nodosum and nodular vasculitis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Erythema nodosum as a rare presentation of pulmonary tuberculosis in adolescents: A case report.Respiratory medicine case reports · 2026Article
- A Wolf in Sheep's Clothing: Extensive Musculoskeletal and Cutaneous TB Masquerading as Primary Erythema Nodosum.Case reports in infectious diseases · 2025Article
- Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation.PLoS genetics · 2023Article
- Characteristics of Serum Autoantibody Repertoire and Immune Subgroup Variation of Tuberculosis-Associated Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Article
- Tuberculosis and Autoimmunity.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022Review
- Erythema Nodosum: A Practical Approach and Diagnostic Algorithm.American journal of clinical dermatology · 2021Review
- Association between erythema nodosum/ erythema induratum of Bazin and Mycobacterium tuberculosis infection in Koreans.Indian journal of dermatology, venereology and leprology · 2021Article
- Erythema Nodosum: A Consequence of Tuberculosis.Cureus · 2019Article
- Prevalence of Auto-antibodies in Pulmonary Tuberculosis.Open forum infectious diseases · 2019Article
- Program-wide review and follow-up of erythema Induratum of Bazin and tuberculosis-associated ocular inflammation management in a TB low-incidence setting: need for improved treatment candidate selection, therapy standardization, and care collaboration.BMC infectious diseases · 2019Article
- Erythema nodosum as sign of primary tuberculosis.Oxford medical case reports · 2017Article
- Human Immunology of Tuberculosis.Microbiology spectrum · 2017Review
- Erythema nodosum and the risk of tuberculosis in a high incidence setting.International journal of circumpolar health · 2016Review
- Erythema nodosum - review of the literature.Reumatologia · 2016Review
- Pulmonary tuberculosis presenting with oral aphthae.European journal of rheumatology · 2015Article
- Seizures in an immunocompromised adolescent: a case report.Journal of medical case reports · 2015Article
- A Case of Tuberculous Granulomatous Panniculitis without Vasculitis.Case reports in dermatologyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMycobacterium tuberculosis (MTB) infection has been suggested to contribute to the pathogenesis of erythema nodosum (EN) and nodular vasculitis (NV), the classic forms of panniculitis. However, there is little evidence to demonstrate the presence of MTB in the skin lesions. This study is aimed at evaluating the association between MTB infection and the development of EN and NV in a Chinese population.
methodsA total of 107 patients (36 EN, 27 NV, and 44 others) with vasculitis and 40 control cases with other skin diseases were recruited and their skin lesion samples were subjected to real time polymerase chain reaction (PCR) analysis of the IS6110 and mpt64 gene fragments of MTB. Their blood mononuclear cells were tested for MTB antigen-specific IFN-γ responses by QuantiFERON®-TB Gold In-Tube (IT) assays.
resultsPCR analysis revealed that 7/23 (30.4%) and 7/18 (38.9%) of the EN and NV samples were positive for the IS6110 DNA, respectively, which were significantly higher than 3/34 (8.8%) of other vasculitis (OV) and 3/40 (7.5%) of the control samples (p<0.05). The nested Real-Time PCR assay indicated that 6/7 (86%) of the IS6110-positive EN samples, all of the IS6110-positive NV and control samples, but only 1/3 of the IS6110-positive OV samples, were positive for the mpt64 gene. Similarly, 19/32 (59.4%) of the EN patients, 20/26 (76.9%) of the NV patients, and 17/36 (47.2%) of the OV patients were positive for MTB antigen-specific IFN-γ responses, which were significantly higher than 6/40 (15%) of the controls (p<0.05).
conclusionOur data strongly suggest that MTB infection and active TB are associated with the development of NV and EN in Chinese.
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