ArticleTheranostics2013
Optimization of optical excitation of upconversion nanoparticles for rapid microscopy and deeper tissue imaging with higher quantum yield.
Article in Theranostics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- AI-driven nanomedicine for cancer theranostics.Molecular cancer · 2026Review
- Fluorescence-Based Mono- and Multimodal Imaging for In Vivo Tracking of Mesenchymal Stem Cells.Biomolecules · 2023Review
- Temperature Sensing in the Short-Wave Infrared Spectral Region Using Core-Shell NaGdFNanomaterials (Basel, Switzerland) · 2020Article
- Near-IR emissive rare-earth nanoparticles for guided surgery.Theranostics · 2020Review
- Local Overheating of Biotissue Labeled With Upconversion Nanoparticles Under YbFrontiers in chemistry · 2020Article
- Breakthroughs in medicine and bioimaging with up-conversion nanoparticles.International journal of nanomedicine · 2019Review
- Dental optical tomography with upconversion nanoparticles-a feasibility study.Journal of biomedical optics · 2017Article
- Upconversion Modulation through Pulsed Laser Excitation for Anti-counterfeiting.Scientific reports · 2017Article
- Current Advances in Lanthanide-Doped Upconversion Nanostructures for Detection and Bioapplication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Optically investigating Nd(3+)-Yb(3+) cascade sensitized upconversion nanoparticles for high resolution, rapid scanning, deep and damage-free bio-imaging.Biomedical optics express · 2015Article
- Theranostic upconversion nanoparticles (II).Theranostics · 2013Article
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5 authors.
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Abstract
Relatively low quantum yield (QY), time-consuming scanning and strong absorption of light in tissue are some of the issues present in the development of upconversion nanoparticles (UCNPs) for biomedical applications. In this paper we systematically optimize several aspects of optical excitation of UCNPs to improve their applicability in bioimaging and biotherapy. A novel multi-photon evanescent wave (EW) excitation modality is proposed for UCNP-based microscopy. The scanning-free, ultrahigh contrast and high spatiotemporal resolution method could simultaneously track a few particles in a large area with a speed of ³⁺up to 350 frames per second. The HeLa cancer cell membrane imaging was successfully performed using NaYF₄: 20% Yb³⁺/2Er³⁺ targeting nanoparticles. Studies with different tissues were made to illustrate the impact of optical property parameters on the deep imaging ability of 920-nm band excitation. In the experiments a semiconductor laser with a 920 nm wavelength was used to excite UCNPs in tissue phantom at five depths. Our experimental and computational results have shown that in UCNP-based diffusion optical imaging with 920-nm laser excitation could lead to larger imaging depth range compared to traditional 974-nm excitation in a wide dynamic range of tissue species. As the QY is power density dependent, a pulsed laser is proposed to improve the QY of UCNPs. This proposal is promising in drastically increasing the imaging depth and efficiency of photodynamic therapy.
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