Evidence map›Paper›PMID 23650407›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2013

Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy.

Brent N Rexer, Yu Shyr, Carlos L Arteaga

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. PTEN Loss Is Associated with Worse Outcome in HER2-Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014
    Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Brent N Rexer
Yu Shyr
Carlos L Arteaga

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
ERBB2 TARGETED ANTITUMOR STRATEGIES IN BREAST CANCERR01CA080195 · NCI · VANDERBILT UNIVERSITY · PI ARTEAGA, CARLOS L · 1999 to 2014
$3.9M
Molecular mechanisms of resistance to HER2 inhibitors in breast cancerK08CA143153 · NCI · VANDERBILT UNIVERSITY · PI REXER, BRENT N · 2010 to 2014
$815k
NCI NIH HHS K08 CA143153NCI NIH HHS P30CA68485NCI NIH HHS P50 CA098131NCI NIH HHS P50CA98131NCI NIH HHS R01 CA080195NCI NIH HHS R01 CA80195
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansPTEN PhosphohydrolaseERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesPTEN PhosphohydrolasePTEN protein, human

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.