ArticleProceedings of the National Academy of Sciences of the United States of America2013
Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 133 citations in OpenAlex.
- Occurrence and characterisation of Toxoplasma gondii infection in free-living Eurasian beavers, Castor fiber, from southern England.Scientific reports · 2025Article
- Early dynamics of Toxoplasma gondii infection in sheep inoculated at mid-gestation with archetypal type II oocysts.Veterinary research · 2025Article
- A major Toxoplasma serine protease inhibitor protects the parasite against gut-derived serine proteases and NETosis damage.The Journal of biological chemistry · 2025Article
- Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling.PLoS pathogens · 2025Article
- Modeling Toxoplasma gondii-gut early interactions using a human microphysiological system.PLoS neglected tropical diseases · 2025Article
- The Intestinal Barrier Protective Effect of Indole Aldehyde Derivatives on AcuteMolecules (Basel, Switzerland) · 2024Article
- Development of an intestinal mucosaJournal of virology · 2024Article
- Host cell-specific metabolism of linoleic acid controlsInfection and immunity · 2024Article
- Effective factors in the pathogenesis ofHeliyon · 2024Review
- Host cell-specific metabolism of linoleic acid controlsbioRxiv : the preprint server for biology · 2024Article
- Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair.American journal of physiology. Cell physiology · 2024Review
- How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections.Trends in parasitology · 2023Review
- Visualization of parasite dynamics in the host tissues: application of tissue transparency technology to parasite research.The Journal of veterinary medical science · 2023Review
- Human neutrophil extracellular traps do not impairFrontiers in immunology · 2023Article
- ExploringFrontiers in cellular and infection microbiology · 2023Review
- A novelDiscovery immunology · 2023Article
- Toxoplasma gondii Dissemination in the Brain Is Facilitated by Infiltrating Peripheral Immune Cells.mBio · 2022Article
- Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system.Science advances · 2022Article
- Intravital and high-content multiplex imaging of the immune system.Trends in cell biology · 2022Review
- Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.Journal of neuroinflammation · 2022Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Toxoplasma gondii infection occurs through the oral route, but we lack important information about how the parasite interacts with the host immune system in the intestine. We used two-photon laser-scanning microscopy in conjunction with a mouse model of oral T. gondii infection to address this issue. T. gondii established discrete foci of infection in the small intestine, eliciting the recruitment and transepithelial migration of neutrophils and inflammatory monocytes. Neutrophils accounted for a high proportion of actively invaded cells, and we provide evidence for a role for transmigrating neutrophils and other immune cells in the spread of T. gondii infection through the lumen of the intestine. Our data identify neutrophils as motile reservoirs of T. gondii infection and suggest a surprising retrograde pathway for parasite spread in the intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.