ArticleProceedings of the National Academy of Sciences of the United States of America2013
Complex history of the amphibian-killing chytrid fungus revealed with genome resequencing data.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.
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Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
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- Host Genus and Habitat Use Shape the Distribution ofEcology and evolution · 2026Article
- Evolution of research on global amphibian declines.Conservation biology : the journal of the Society for Conservation Biology · 2026Review
- Patterns and mechanisms of fungal genome plasticity.Current biology : CB · 2025Review
- Comparative Genomics Reveals Intra and Inter Species Variation in the Pathogenic Fungus Batrachochytrium dendrobatidis.Genome biology and evolution · 2025Article
- How to Validate a Bayesian Evolutionary Model.Systematic biology · 2025Article
- A near-complete telomere-to-telomere genome assembly for Batrachochytrium dendrobatidis GPL JEL423 reveals a larger CBM18 gene family and a smaller M36 metalloprotease gene family than previously recognized.G3 (Bethesda, Md.) · 2025Article
- Current Approaches in Genome Assembly of Human Fungal Pathogens.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Landscape-scale drivers of spatial dynamics and genetic diversity in an emerging wildlife pathogen.Oecologia · 2024Article
- Genome variation in the Batrachochytrium pathogens of amphibians.PLoS pathogens · 2024Review
- Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis.Frontiers in cell and developmental biology · 2024Review
- Chytrid infections exhibit historical spread and contemporary seasonality in a declining stream-breeding frog.Royal Society open science · 2024Article
- Major Emerging Fungal Diseases of Reptiles and Amphibians.Pathogens (Basel, Switzerland) · 2023Review
- Immune priming prior to pathogen exposure sheds light on the relationship between host, microbiome and pathogen in disease.Royal Society open science · 2023Article
- A Universal and Efficient Detection of Chytridiomycosis Infections in Amphibians Using Novel Quantitative PCR Markers.Transboundary and emerging diseases · 2023Article
- Article
- Diploid-dominant life cycles characterize the early evolution of Fungi.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Biodiversity is decimated by the cascading effects of the amphibian-killing chytrid fungus.PLoS pathogens · 2022Article
51 more citing papers are in PubMed but not listed here.
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20 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Understanding the evolutionary history of microbial pathogens is critical for mitigating the impacts of emerging infectious diseases on economically and ecologically important host species. We used a genome resequencing approach to resolve the evolutionary history of an important microbial pathogen, the chytrid Batrachochytrium dendrobatidis (Bd), which has been implicated in amphibian declines worldwide. We sequenced the genomes of 29 isolates of Bd from around the world, with an emphasis on North, Central, and South America because of the devastating effect that Bd has had on amphibian populations in the New World. We found a substantial amount of evolutionary complexity in Bd with deep phylogenetic diversity that predates observed global amphibian declines. By investigating the entire genome, we found that even the most recently evolved Bd clade (termed the global panzootic lineage) contained more genetic variation than previously reported. We also found dramatic differences among isolates and among genomic regions in chromosomal copy number and patterns of heterozygosity, suggesting complex and heterogeneous genome dynamics. Finally, we report evidence for selection acting on the Bd genome, supporting the hypothesis that protease genes are important in evolutionary transitions in this group. Bd is considered an emerging pathogen because of its recent effects on amphibians, but our data indicate that it has a complex evolutionary history that predates recent disease outbreaks. Therefore, it is important to consider the contemporary effects of Bd in a broader evolutionary context and identify specific mechanisms that may have led to shifts in virulence in this system.
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