ArticleProceedings of the National Academy of Sciences of the United States of America2013
Gene regulatory network for neurogenesis in a sea star embryo connects broad neural specification and localized patterning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 82 citations in OpenAlex.
- The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning.PLoS biology · 2026Article
- A stage and anatomy ontology for embryogenesis in indirect-developing echinoderms.Development (Cambridge, England) · 2026Article
- An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos.Journal of developmental biology · 2025Review
- Anterior-Posterior Wnt Signaling Network Conservation between Indirect Developing Sea Urchin and Hemichordate Embryos.Integrative and comparative biology · 2024Article
- Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium.Development (Cambridge, England) · 2024Article
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms.EvoDevo · 2023Article
- Article
- Gene regulatory divergence amongst echinoderms underlies appearance of pigment cells in sea urchin development.Developmental biology · 2023Article
- Single-cell RNA-sequencing analysis of early sea star development.Development (Cambridge, England) · 2022Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Neurogenesis during Brittle Star Arm Regeneration Is Characterised by a Conserved Set of Key Developmental Genes.Biology · 2022Article
- Lineage tracing shows that cell size asymmetries predict the dorsoventral axis in the sea star embryo.BMC biology · 2022Article
- Regeneration of the larval sea star nervous system by wounding induced respecification to the Sox2 lineage.eLife · 2022Article
- Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- Transcriptomic analysis of Nodal - and BMP- associated genes during development to the juvenile seastar in Parvulastra exigua (Asterinidae).Marine genomics · 2021Article
- The Development and Neuronal Complexity of Bipinnaria Larvae of the Sea Star Asterias rubens.Integrative and comparative biology · 2021Article
- Article
- Systematic comparison of sea urchin and sea star developmental gene regulatory networks explains how novelty is incorporated in early development.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A great challenge in development biology is to understand how interacting networks of regulatory genes can direct the often highly complex patterning of cells in a 3D embryo. Here, we detail the gene regulatory network that describes the distribution of ciliary band-associated neurons in the bipinnaria larva of the sea star. This larva, typically for the ancestral deuterostome dipleurula larval type that it represents, forms two loops of ciliary bands that extend across much of the anterior-posterior and dorsal-ventral ectoderm. We show that the sea star first likely uses maternally inherited factors and the Wnt and Delta pathways to distinguish neurogenic ectoderm from endomesoderm. The broad neurogenic potential of the ectoderm persists throughout much of gastrulation. Nodal, bone morphogenetic protein 2/4 (Bmp2/4), and Six3-dependent pathways then sculpt a complex ciliary band territory that is defined by the expression of the forkhead transcription factor, foxg. Foxg is needed to define two molecularly distinct ectodermal domains, and for the formation of differentiated neurons along the edge of these two territories. Thus, significantly, Bmp2/4 signaling in sea stars does not distinguish differentiated neurons from nonneuronal ectoderm as it does in many other animals, but instead contributes to the patterning of an ectodermal territory, which then, in turn, provides cues to permit the final steps of neuronal differentiation. The modularity between specification and patterning likely reflects the evolutionary history of this gene regulatory network, in which an ancient module for specification of a broad neurogenic potential ectoderm was subsequently overlaid with a module for patterning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.