ArticleProceedings of the National Academy of Sciences of the United States of America2013
Retargeting of the Bacillus thuringiensis toxin Cyt2Aa against hemipteran insect pests.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- CanPlants (Basel, Switzerland) · 2026Article
- A Mechanistic Model of Cry2Ab12 Toxicity AgainstToxins · 2026Article
- Basic Research on Whitefly Molecular Biology: A Foundation for Innovative Pest Management Strategies.Current issues in molecular biology · 2026Review
- Generation of an Insecticidal Human Domain Antibody from a Phage Library TargetingCurrent issues in molecular biology · 2026Article
- Biological functions of Crystal toxin proteins and their secondary metabolites in targeting rugose spiralling whitefly Aleurodicus rugioperculatus.Current microbiology · 2025Article
- Gut-binding peptides as potential tools to reduce virus binding to honey bee gut surface proteins.Applied and environmental microbiology · 2025Article
- Diversity of transgenes in sustainable management of insect pests.Transgenic research · 2023Review
- Mutation of a Threonine Residue in αD-β4 Loop of Cyt2Aa2 Protein Influences Binding on Fluid Lipid Membranes.Toxins · 2023Article
- Cry1Ba1-mediated toxicity of transgenicFrontiers in insect science · 2023Article
- Peptide mediated, enhanced toxicity of a bacterial pesticidal protein against southern green stink bug.Microbial biotechnology · 2022Article
- Dynamics in Pest Status of Phytophagous Stink Bugs in the Neotropics.Neotropical entomology · 2022Review
- Engineering of Cry3Bb1 provides mechanistic insights toward countering western corn rootworm resistance.Current research in insect science · 2022Article
- Biotechnological Approaches for Host Plant Resistance to Insect Pests.Frontiers in genetics · 2022Review
- Genetic Modification ofFrontiers in plant science · 2022Article
- A sugarcane mosaic virus vector for rapid in planta screening of proteins that inhibit the growth of insect herbivores.Plant biotechnology journal · 2021Article
- Streamlined phage display library protocols for identification of insect gut binding peptides highlight peptide specificity.Current research in insect science · 2021Article
- The Cytocidal Spectrum ofToxins · 2020Review
- Genetic engineering of crops for insect resistance: An overview.Journal of biosciences · 2020Article
- Structural characterization and heterologous expression of a new cyt gene cloned from Bacillus thuringiensis.Journal of molecular modeling · 2019Article
- Toxicity ofToxins · 2019Article
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7 authors.
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Abstract
Although transgenic crops expressing Bacillus thuringiensis (Bt) toxins have been used successfully for management of lepidopteran and coleopteran pest species, the sap-sucking insects (Hemiptera) are not particularly susceptible to Bt toxins. To overcome this limitation, we demonstrate that addition of a short peptide sequence selected for binding to the gut of the targeted pest species serves to increase toxicity against said pest. Insertion of a 12-aa pea aphid gut-binding peptide by adding to or replacing amino acids in one of three loops of the Bt cytolytic toxin, Cyt2Aa, resulted in enhanced binding and toxicity against both the pea aphid, Acyrthosiphon pisum, and the green peach aphid, Myzus persicae. This strategy may allow for transgenic plant-mediated suppression of other hemipteran pests, which include some of the most important pests of global agriculture.
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