SynthesisPediatrics2013
Allergen-specific immunotherapy for pediatric asthma and rhinoconjunctivitis: a systematic review.
Synthesis in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Clinical Practice Guideline: Immunotherapy for Inhalant Allergy.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Guideline
- Pooled it
- Efficacy and safety of subcutaneous immunotherapy in asthmatic children allergic to house dust mite: a meta-analysis and systematic review.Frontiers in pediatrics · 2023Review
- Effectiveness of sublingual immunotherapy with house dust mite drops in asthmatic children at different ages.Frontiers in pediatrics · 2023Article
- Effectiveness and safety of a microcrystalline tyrosine-adjuvanted Dermatophagoides pteronyssinus allergoid immunotherapy in adult patients with allergic asthma and rhinitis: A real-life prospective observational study.Immunity, inflammation and disease · 2022Observational
- Metabolomics Reveals Process of Allergic Rhinitis Patients with Single- and Double-Species Mite Subcutaneous Immunotherapy.Metabolites · 2021Article
- Intradermal Testing Results in Horses Affected by Mild-Moderate and Severe Equine Asthma.Animals : an open access journal from MDPI · 2021Article
- Article
- Use of Sublingual Immunotherapy for Aeroallergens in Children with Asthma.Journal of clinical medicine · 2020Review
- Allergen Immunotherapy in Pediatric Asthma: A Pragmatic Point of View.Children (Basel, Switzerland) · 2020Review
- EAACI Allergen Immunotherapy User's Guide.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Review
- Demographic and medical factors affecting short-term changes in subjective evaluation of asthma control in adolescents.Postepy dermatologii i alergologii · 2018Article
- International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.International forum of allergy & rhinology · 2018Article
- Immunotherapy and Asthma in Children.Frontiers in pediatrics · 2018Review
- Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report.Italian journal of pediatrics · 2017Review
- Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic overview of systematic reviews.Clinical and translational allergy · 2017Review
- Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children.Frontiers in pediatrics · 2017Review
- Allergic respiratory disease (ARD), setting forth the basics: proposals of an expert consensus report.Clinical and translational allergy · 2017Article
- Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews.Clinical and translational allergy · 2017Review
- Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management.World journal of methodology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveSubcutaneous immunotherapy (SCIT) is approved in the United States for the treatment of pediatric asthma and rhinitis; sublingual immunotherapy (SLIT) does not have regulatory approval but is used in clinical practice. The objective of this study was to systematically review the evidence regarding the efficacy and safety of SCIT and SLIT for the treatment of pediatric asthma and allergic rhinoconjunctivitis.
methodsTwo independent reviewers selected articles for inclusion, extracted data, and graded the strength of evidence for each clinical outcome. All studies were randomized controlled trials of children with allergic asthma or rhinoconjunctivitis treated with SCIT or an aqueous formulation of SLIT. Data sources were Medline, Embase, LILACS, CENTRAL, and the Cochrane Central Register of Controlled Trials through May 2012.
resultsIn 13 trials, 920 children received SCIT or usual care; in 18 studies, 1583 children received SLIT or usual care. Three studies compared SCIT with SLIT head-to-head in 135 children. The strength of evidence is moderate that SCIT improves asthma and rhinitis symptoms and low that SCIT improves conjunctivitis symptoms and asthma medication scores. Strength of evidence is high that SLIT improves asthma symptoms and moderate that SLIT improves rhinitis and conjunctivitis symptoms and decreases medication usage. The evidence is low to support SCIT over SLIT for improving asthma or rhinitis symptoms or medication usage. Local reactions were frequent with SCIT and SLIT. There was 1 report of anaphylaxis with SCIT.
conclusionsEvidence supports the efficacy of both SCIT and SLIT for the treatment of asthma and rhinitis in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.