ArticleMolecular nutrition & food research2013
LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: implications for mitochondrial dysfunction associated with Parkinson's disease.
Article in Molecular nutrition & food research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease.American journal of physiology. Heart and circulatory physiology · 2020Article
- Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death.Free radical biology & medicine · 2020Review
- Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation.Frontiers in endocrinology · 2020Review
- Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function.The Journal of biological chemistry · 2019Article
- Redox (phospho)lipidomics of signaling in inflammation and programmed cell death.Journal of leukocyte biology · 2019Review
- "Redox lipidomics technology: Looking for a needle in a haystack".Chemistry and physics of lipids · 2019Review
- The Role of Lipids in Parkinson's Disease.Cells · 2019Review
- Disentangling oxidation/hydrolysis reactions of brain mitochondrial cardiolipins in pathogenesis of traumatic injury.JCI insight · 2018Article
- Comparing phospholipid profiles of mitochondria and whole tissue: Higher PUFA content in mitochondria is driven by increased phosphatidylcholine unsaturation.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2018Article
- Molecular structural diversity of mitochondrial cardiolipins.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Distinct membrane properties are differentially influenced by cardiolipin content and acyl chain composition in biomimetic membranes.Biochimica et biophysica acta. Biomembranes · 2017Article
- Known unknowns of cardiolipin signaling: The best is yet to come.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals.ACS chemical biology · 2016Article
- Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function.PloS one · 2016Article
- LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease.Free radical research · 2015Article
- Effects of cardiolipin on membrane morphology: a Langmuir monolayer study.Biophysical journal · 2015Article
- Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry.BBA clinical · 2014Article
- Characterization of cardiolipins and their oxidation products by LC-MS analysis.Chemistry and physics of lipids · 2014Review
- First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.British journal of pharmacology · 2014Review
- Mitochondrial stress signaling promotes cellular adaptations.International journal of cell biology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
scopeRotenone is a toxicant believed to contribute to the development of Parkinson's disease. METHODS AND
resultsUsing human peripheral blood lymphocytes we demonstrated that exposure to rotenone resulted in disruption of electron transport accompanied by the production of reactive oxygen species, development of apoptosis and elevation of peroxidase activity of mitochondria. Employing LC/MS-based lipidomics/oxidative lipidomics we characterized molecular species of cardiolipin (CL) and its oxidation/hydrolysis products formed early in apoptosis and associated with the rotenone-induced mitochondrial dysfunction.
conclusionThe major oxidized CL species - tetra-linoleoyl-CL - underwent oxidation to yield epoxy-C18:2 and dihydroxy-C18:2 derivatives predominantly localized in sn-1 and sn-2 positions, respectively. In addition, accumulation of mono-lyso-CL species and oxygenated free C18:2 were detected in rotenone-treated lymphocytes. These oxidation/hydrolysis products may be useful for the development of new biomarkers of mitochondrial dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.