ArticleEukaryotic cell2013
Discovery of a sexual cycle in Aspergillus lentulus, a close relative of A. fumigatus.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Comparison of Morphological, Virulence, and Antifungal Susceptibility Characteristics WithinInfection and drug resistance · 2025Article
- Examining Signatures of Natural Selection in Antifungal Resistance Genes AcrossFrontiers in fungal biology · 2021Article
- Global Sexual Fertility in the Opportunistic PathogenJournal of fungi (Basel, Switzerland) · 2020Article
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019Review
- Article
- Unravelling species boundaries in thePersoonia · 2018Article
- Evolution of asexual and sexual reproduction in the aspergilli.Studies in mycology · 2018Article
- New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones.Engineering in life sciences · 2018Review
- Sex and the Imperfect Fungi.Microbiology spectrum · 2017Review
- Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species.Microbial biotechnology · 2017Review
- Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Aspergillus fumigatus-Related Species in Clinical Practice.Frontiers in microbiology · 2016Review
- Early invasive pulmonary aspergillosis in a kidney transplant recipient caused by Aspergillus lentulus: first Brazilian report.Mycopathologia · 2015Article
- Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati.Frontiers in microbiology · 2015Review
- Aspergillus: sex and recombination.Mycopathologia · 2014Review
- Aspergillus fumigatus and related species.Cold Spring Harbor perspectives in medicine · 2014Review
- Fungi associated with drug recalls and rare disease outbreaks.Journal of industrial microbiology & biotechnology · 2014Review
- Genetic relatedness versus biological compatibility between Aspergillus fumigatus and related species.Journal of clinical microbiology · 2014Article
- Sexual reproduction of human fungal pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
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Authors and funding
4 authors.
Funding
Abstract
Aspergillus lentulus was described in 2005 as a new species within the A. fumigatus sensu lato complex. It is an opportunistic human pathogen causing invasive aspergillosis with high mortality rates, and it has been isolated from clinical and environmental sources. The species is morphologically nearly identical to A. fumigatus sensu stricto, and this similarity has resulted in their frequent misidentification. Comparative studies show that A. lentulus has some distinguishing growth features and decreased in vitro susceptibility to several antifungal agents, including amphotericin B and caspofungin. Similar to the once-presumed-asexual A. fumigatus, it has only been known to reproduce mitotically. However, we now show that A. lentulus has a heterothallic sexual breeding system. A PCR-based mating-type diagnostic detected isolates of either the MAT1-1 or MAT1-2 genotype, and examination of 26 worldwide clinical and environmental isolates revealed similar ratios of the two mating types (38% versus 62%, respectively). MAT1-1 and MAT1-2 idiomorph regions were analyzed, revealing the presence of characteristic alpha and high-mobility-group (HMG) domain genes, together with other more unusual features such as a MAT1-2-4 gene. We then demonstrated that A. lentulus possesses a functional sexual cycle with mature cleistothecia, containing heat-resistant ascospores, being produced after 3 weeks of incubation. Recombination was confirmed using molecular markers. However, isolates of A. lentulus failed to cross with highly fertile strains of A. fumigatus, demonstrating reproductive isolation between these sibling species. The discovery of the A. lentulus sexual stage has significant implications for the management of drug resistance and control of invasive aspergillosis associated with this emerging fungal pathogen.
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