ArticleInternational journal of cancer2013
Tubal ligation, hysterectomy and epithelial ovarian cancer in the New England Case-Control Study.
Article in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The Association between Endometriosis, Tubal Ligation, Hysterectomy and Epithelial Ovarian Cancer: Meta-Analyses.International journal of environmental research and public health · 2016Pooled it
- Association of hysterectomy and invasive epithelial ovarian and tubal cancer: a cohort study within UKCTOCS.BJOG : an international journal of obstetrics and gynaecology · 2022Trial
- Prevention of Epithelial Ovarian Cancer.Cold Spring Harbor perspectives in medicine · 2023Review
- Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis.International journal of molecular sciences · 2023Review
- Epidemiology and risk factors for ovarian cancer.Przeglad menopauzalny = Menopause review · 2023Review
- Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.Gynecologic oncology · 2022Article
- Repeated hyperstimulation affects the ultrastructure of mouse fallopian tube epithelium.The Journal of reproduction and development · 2020Article
- Subsequent Development of Epithelial Ovarian Cancer After Ovarian Surgery for Benign Ovarian Tumor: A Population-Based Cohort Study.Clinical epidemiology · 2020Article
- Article
- The Association Between Hysterectomy and Ovarian Cancer Risk: A Population-Based Record-Linkage Study.Journal of the National Cancer Institute · 2019Article
- The cost-effectiveness of opportunistic salpingectomy versus standard tubal ligation at the time of cesarean delivery for ovarian cancer risk reduction.Gynecologic oncology · 2019Article
- Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study.Cancer causes & control : CCC · 2018Article
- Bilateral salpingectomy to reduce the risk of ovarian/fallopian/peritoneal cancer in women at average risk: a position statement of the Korean Society of Obstetrics and Gynecology (KSOG).Obstetrics & gynecology science · 2018Review
- Article
- Endometriosis is the independent prognostic factor for survival in Chinese patients with epithelial ovarian carcinoma.Journal of ovarian research · 2017Article
- Tubal ligation and ovarian cancer risk in African American women.Cancer causes & control : CCC · 2017Article
- Review
- A prospective study of reproductive factors and exogenous hormone use in relation to ovarian cancer risk among Black women.Cancer causes & control : CCC · 2017Article
- Epidemiology of ovarian cancer: a review.Cancer biology & medicine · 2017Article
- Tubal Ligation Induces Quiescence in the Epithelia of the Fallopian Tube Fimbria.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies have observed that tubal ligation and hysterectomy are associated with a decreased risk of ovarian cancer; however, little is known about whether these associations vary by surgical characteristics, individual characteristics or tumor histology. We used logistic regression to examine tubal ligation, simple hysterectomy and hysterectomy with unilateral oophorectomy in relation to risk of epithelial ovarian cancer in the New England Case-Control Study. Our primary analysis included 2,265 cases and 2,333 controls. Overall, tubal ligation was associated with a lower risk of epithelial ovarian cancer [odds ratio (OR) = 0.82, 95% confidence interval (CI): 0.68-0.97], especially for endometrioid tumors (OR = 0.45, 95% CI: 0.29-0.69). The inverse association between tubal ligation and ovarian cancer risk was stronger for women who had undergone the procedure at the time of last delivery (OR = 0.60, 95% CI: 0.42-0.84) rather than at a later time (OR = 0.93, 95% CI: 0.75-1.15). Overall, simple hysterectomy was not associated with ovarian cancer risk (OR: 1.09, 95% CI: 0.83-1.42), although it was associated with a nonsignificant decreased risk of ovarian cancer among women who underwent the procedure at age 45 or older (RR: 0.64, 95% CI: 0.40-1.02) or within the last 10 years (OR = 0.65, 95% CI: 0.38-1.13). Overall, women who had a hysterectomy with a unilateral oophorectomy had significantly lower risk of ovarian cancer (OR = 0.65, 95% CI: 0.45-0.94). In summary, tubal ligation and hysterectomy with unilateral oophorectomy were inversely associated with ovarian cancer risk in a large population-based case-control study. Additional research is necessary to understand the potential biologic mechanisms by which these procedures may reduce ovarian cancer risk.
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Registered trials
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