ArticleAnnals of biomedical engineering2013
High sensitivity micro-elastometry: applications in blood coagulopathy.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy.Physics in medicine and biology · 2022Article
- Assessing TEG6S reliability between devices and across multiple time points: A prospective thromboelastography validation study.Scientific reports · 2020Article
- Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study.BMC anesthesiology · 2019Observational
- Acoustic radiation force optical coherence elastography for elasticity assessment of soft tissues.Applied spectroscopy reviews · 2019Article
- Fibrin mechanical properties and their structural origins.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Dynamic and quantitative assessment of blood coagulation using optical coherence elastography.Scientific reports · 2016Article
- A portable blood plasma clot micro-elastometry device based on resonant acoustic spectroscopy.The Review of scientific instruments · 2015Article
- Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs).Lab on a chip · 2015Article
- Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Highly sensitive methods for the assessment of clot structure can aid in our understanding of coagulation disorders and their risk factors. Rapid and simple clot diagnostic systems are also needed for directing treatment in a broad spectrum of cardiovascular diseases. Here we demonstrate a method for micro-elastometry, named resonant acoustic spectroscopy with optical vibrometry (RASOV), which measures the clot elastic modulus (CEM) from the intrinsic resonant frequency of a clot inside a microwell. We observed a high correlation between the CEM of human blood measured by RASOV and a commercial thromboelastograph (TEG), (R = 0.966). Unlike TEG, RASOV requires only 150 μL of sample and offers improved repeatability. Since CEM is known to primarily depend upon fibrin content and network structure, we investigated the CEM of purified clots formed with varying amounts of fibrinogen and thrombin. We found that RASOV was sensitive to changes of fibrinogen content (0.5-6 mg/mL), as well as to the amount of fibrinogen converted to fibrin during clot formation. We then simulated plasma hypercoagulability via hyperfibrinogenemia by spiking whole blood to 150 and 200% of normal fibrinogen levels, and subsequently found that RASOV could detect hyperfibrinogenemia-induced changes in CEM and distinguish these conditions from normal blood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.