ArticleBrain imaging and behavior2013
Effects of smoking on D₂/D₃ striatal receptor availability in alcoholics and social drinkers.
Article in Brain imaging and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.Psychopharmacology · 2019Pooled it
- Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Lower Striatal Dopamine D2 Receptor Availability in Individuals Who Test Positive for Quantitated Urine Metabolites of Tobacco and/or Marijuana Smoke.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Intra-striatal dopaminergic inter-subject covariance in social drinkers and non-treatment-seeking alcohol use disorder participants.Addiction biology · 2024Article
- Greater ventral striatal functional connectivity in cigarette smokers relative to non-smokers across a spectrum of alcohol consumption.Brain imaging and behavior · 2024Article
- Schizophrenia mediating the effect of smoking phenotypes on antisocial behavior: A Mendelian randomization analysis.CNS neuroscience & therapeutics · 2024Article
- Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect.Pharmacological reviews · 2023Review
- Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- Dopamine Transporter Gene Methylation is Associated with Nucleus Accumbens Activation During Reward Processing in Healthy but not Alcohol-Dependent Individuals.Alcoholism, clinical and experimental research · 2018Article
- Striatal Dopamine D2/D3 Receptor Availability Varies Across Smoking Status.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- A review of positron emission tomography studies exploring the dopaminergic system in substance use with a focus on tobacco as a co-variate.The American journal of drug and alcohol abuse · 2017Review
- Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics.Drug and alcohol dependence · 2016Article
- How Imaging Glutamate, γ-Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal.Alcoholism, clinical and experimental research · 2015Review
- Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity.Neuropharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Studies have reported lower striatal D₂/D₃ receptor availability in both alcoholics and cigarette smokers relative to healthy controls. These substances are commonly co-abused, yet the relationship between comorbid alcohol/tobacco abuse and striatal D₂/D₃ receptor availability has not been examined. We sought to determine the degree to which dual abuse of alcohol and tobacco is associated with lower D₂/D₃ receptor availability. Eighty-one subjects (34 nontreatment-seeking alcoholic smokers [NTS-S], 21 social-drinking smokers [SD-S], and 26 social-drinking non-smokers [SD-NS]) received baseline [(11)C]raclopride scans. D₂/D₃ binding potential (BPND ≡ Bavail/KD) was estimated for ten anatomically defined striatal regions of interest (ROIs). Significant group effects were detected in bilateral pre-commissural dorsal putamen, bilateral pre-commissural dorsal caudate; and bilateral post-commissural dorsal putamen. Post-hoc testing revealed that, regardless of drinking status, smokers had lower D₂/D₃ receptor availability than non-smoking controls. Chronic tobacco smokers have lower striatal D₂/D₃ receptor availability than non-smokers, independent of alcohol use. Additional studies are needed to identify the mechanisms by which chronic tobacco smoking is associated with striatal dopamine receptor availability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.