ArticleNucleic acids research2013
The mTERF protein MOC1 terminates mitochondrial DNA transcription in the unicellular green alga Chlamydomonas reinhardtii.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Article
- The Impact of Mitochondrial DNA Depletion on Mitochondrial Ultrastructure, Photosynthesis, and the mTERF Gene Family inInternational journal of molecular sciences · 2026Article
- Genome-Wide Identification and Characterization of the mTERF Gene Family in Spinach and the Role ofPlants (Basel, Switzerland) · 2025Article
- A cyclical marker system enables indefinite series of oligonucleotide-directed gene editing in Chlamydomonas reinhardtii.Plant physiology · 2024Article
- Analysis of the TomatoPlants (Basel, Switzerland) · 2023Article
- Plant organellar RNA maturation.The Plant cell · 2023Review
- How to build a ribosome from RNA fragments in Chlamydomonas mitochondria.Nature communications · 2021Article
- Mitochondrial Transcription Termination Factor 27 Is Required for Salt Tolerance inInternational journal of molecular sciences · 2021Article
- Review
- mTERF8, a Member of the Mitochondrial Transcription Termination Factor Family, Is Involved in the Transcription Termination of Chloroplast GenePlant physiology · 2020Article
- Genome-Wide Identification and Characterization of the Mitochondrial Transcription Termination Factors (mTERFs) inInternational journal of molecular sciences · 2019Article
- Prognostic roles of mitochondrial transcription termination factors in non-small cell lung cancer.Oncology letters · 2019Article
- A Mitochondrial Transcription Termination Factor,G3 (Bethesda, Md.) · 2019Article
- Transcriptional and Post-transcriptional Regulation of Organellar Gene Expression (OGE) and Its Roles in Plant Salt Tolerance.International journal of molecular sciences · 2019Review
- The mitochondrial alternative oxidase fromThe Journal of biological chemistry · 2019Article
- The Characterization of ArabidopsisInternational journal of molecular sciences · 2018Article
- A nuclear-encoded protein, mTERF6, mediates transcription termination of rpoA polycistron for plastid-encoded RNA polymerase-dependent chloroplast gene expression and chloroplast development.Scientific reports · 2018Article
- Control of organelle gene expression by the mitochondrial transcription termination factor mTERF22 in Arabidopsis thaliana plants.PloS one · 2018Article
- Impaired Mitochondrial Transcription Termination Disrupts the Stromal Redox Poise inPlant physiology · 2017Article
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2 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The molecular function of mTERFs (mitochondrial transcription termination factors) has so far only been described for metazoan members of the protein family and in animals they control mitochondrial replication, transcription and translation. Cells of photosynthetic eukaryotes harbour chloroplasts and mitochondria, which are in an intense cross-talk that is vital for photosynthesis. Chlamydomonas reinhardtii is a unicellular green alga widely used as a model organism for photosynthesis research and green biotechnology. Among the six nuclear C. reinhardtii mTERF genes is mTERF-like gene of Chlamydomonas (MOC1), whose inactivation alters mitorespiration and interestingly also light-acclimation processes in the chloroplast that favour the enhanced production of biohydrogen. We show here from in vitro studies that MOC1 binds specifically to a sequence within the mitochondrial rRNA-coding module S3, and that a knockout of MOC1 in the mutant stm6 increases read-through transcription at this site, indicating that MOC1 acts as a transcription terminator in vivo. Whereas the level of certain antisense RNA species is higher in stm6, the amount of unprocessed mitochondrial sense transcripts is strongly reduced, demonstrating that a loss of MOC1 causes perturbed mitochondrial DNA (mtDNA) expression. Overall, we provide evidence for the existence of mitochondrial antisense RNAs in C. reinhardtii and show that mTERF-mediated transcription termination is an evolutionary-conserved mechanism occurring in phototrophic protists and metazoans.
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