ArticleBlood2013
Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire.
Article in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity.Nature communications · 2025Article
- Review
- NK cell-activating receptor NKp46 does not participate in the development of obesity-induced inflammation and insulin resistance.Molecules and cells · 2024Article
- The Power of Three: Nanomaterials for Natural Killer (NK) Cell Immunoengineering Maximize Their Potency if They Exploit Multireceptor Stimulation.Advanced healthcare materials · 2024Article
- Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness.Frontiers in immunology · 2023Article
- Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration.Frontiers in immunology · 2022Article
- Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium.Immunity · 2021Article
- NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection.PLoS pathogens · 2019Article
- CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.Nature immunology · 2018Article
- Dependence of innate lymphoid cell 1 development on NKp46.PLoS biology · 2018Article
- The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s.Cell reports · 2018Article
- NKG2D: A Master Regulator of Immune Cell Responsiveness.Frontiers in immunology · 2018Review
- Article
- Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression.Scientific reports · 2017Article
- Expression and function of NKp46 W32R: the human homologous protein of mouse NKp46 W32R (Noé).Scientific reports · 2017Article
- The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.Nature communications · 2017Article
- Chronic NKG2D EngagementFrontiers in immunology · 2017Article
- Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection.Science (New York, N.Y.) · 2015Article
- Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The immunoreceptors NKG2D and NKp46 are known for their capacity to activate natural killer (NK) cell cytotoxicity and secretory responses in the contexts of tumors and infections, yet their roles in NK cell education remain unclear. Here, we provide the first characterization of mice deficient for both NKG2D and NKp46 receptors to address the relevance of their concomitant absence during NK cell development and function. Our findings reveal that NK cells develop normally in double-mutant (DKO) mice. Mice lacking NKG2D but not NKp46 showed subtle differences in the percentages of NK cells expressing inhibitory Ly49 receptors and the adhesion molecule DNAM-1. A slightly increased percentage of terminally differentiated NK cells and functional response to in vitro stimuli was observed in some experiments. These alterations were modest and did not affect NK cell function in vivo in response to mouse cytomegalovirus infection. NKp46 deficiency alone, or in combination with NKG2D deficiency, had no effect on frequency or function of NK cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.