GuidelineChest2013
Screening for lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Guideline in Chest, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03487952 (Evaluation of Lung Nodule and Lung Cancer Detection With Artificial Intelligence Assisted Computed Tomography Among People Living in North China), which is not on this map. Cited by 200 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Lung Nodule and Lung Cancer Detection With Artificial Intelligence Assisted Computed Tomography Among People Living in North China: a Prospective Single-arm Multicentre Study of Screening
Who cites it
200 citing papers in PubMed, 11 syntheses or guidelines pooled it, 403 citations in OpenAlex.
- The prevalence of comorbidity in the lung cancer screening population: A systematic review and meta-analysis.Journal of medical screening · 2023Pooled it
- Guideline
- Guideline
- Insufficient uptake of systematic search methods in oncological clinical practice guideline: a systematic review.BMC medical research methodology · 2019Pooled it
- Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Stakeholder Research Priorities for Smoking Cessation Interventions within Lung Cancer Screening Programs. An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2017Guideline
- [Systematic Review of the Methodology Quality in Lung Cancer Screening Guidelines].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Pooled it
- An official American Thoracic Society/American College of Chest Physicians policy statement: implementation of low-dose computed tomography lung cancer screening programs in clinical practice.American journal of respiratory and critical care medicine · 2015Guideline
- ESR/ERS white paper on lung cancer screening.European radiology · 2015Guideline
- Guideline
- Guideline
- Optimizing Longitudinal Tobacco Cessation Treatment in Lung Cancer Screening: A Sequential, Multiple Assignment, Randomized Trial.JAMA network open · 2023Trial
- Aiding shared decision making in lung cancer screening: two decision tools.Journal of public health (Oxford, England) · 2021Trial
- Effect of a Patient Decision Aid on Lung Cancer Screening Decision-Making by Persons Who Smoke: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Program for lung cancer screening and tobacco cessation: Study protocol of a sequential, multiple assignment, randomized trial.Contemporary clinical trials · 2017Trial
- The Relations Between False Positive and Negative Screens and Smoking Cessation and Relapse in the National Lung Screening Trial: Implications for Public Health.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Trial
- The impact of radiologists' expertise on screen results decisions in a CT lung cancer screening trial.European radiology · 2015Trial
- Electromagnetic navigation bronchoscopy-guided three-dimensional conformal microwave ablation for unresectable peripheral high-risk pulmonary nodules: a mid-term assessment with no real-time intraoperative CT/cone-beam computed tomography guidance.Translational lung cancer research · 2026Article
- Real-world diagnostic pathways and treatment patterns for suspected lung cancer in Japan: a nationwide claims database analysis.ESMO real world data and digital oncology · 2026Article
- Perioperative safety and risk stratification of simultaneous resection for multiple pulmonary nodules via video-assisted thoracoscopic surgery: a retrospective cohort study.Translational lung cancer research · 2026Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLung cancer is by far the major cause of cancer deaths largely because in the majority of patients it is at an advanced stage at the time it is discovered, when curative treatment is no longer feasible. This article examines the data regarding the ability of screening to decrease the number of lung cancer deaths.
methodsA systematic review was conducted of controlled studies that address the effectiveness of methods of screening for lung cancer.
resultsSeveral large randomized controlled trials (RCTs), including a recent one, have demonstrated that screening for lung cancer using a chest radiograph does not reduce the number of deaths from lung cancer. One large RCT involving low-dose CT (LDCT) screening demonstrated a significant reduction in lung cancer deaths, with few harms to individuals at elevated risk when done in the context of a structured program of selection, screening, evaluation, and management of the relatively high number of benign abnormalities. Whether other RCTs involving LDCT screening are consistent is unclear because data are limited or not yet mature.
conclusionsScreening is a complex interplay of selection (a population with sufficient risk and few serious comorbidities), the value of the screening test, the interval between screening tests, the availability of effective treatment, the risk of complications or harms as a result of screening, and the degree with which the screened individuals comply with screening and treatment recommendations. Screening with LDCT of appropriate individuals in the context of a structured process is associated with a significant reduction in the number of lung cancer deaths in the screened population. Given the complex interplay of factors inherent in screening, many questions remain on how to effectively implement screening on a broader scale.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.