ArticleHerz2014
Serial evaluation of hepatic function profile after Fontan operation.
Article in Herz, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Childhood Liver-Related Abnormalities After Fontan Completion: Evidence from a 20-Year Tertiary Centre Cohort.Pediatric cardiology · 2026Article
- A computational investigation on the total cavopulmonary connection circulation assisted by an axial flow pump.Frontiers in bioengineering and biotechnology · 2025Article
- Feasibility, classification and potential clinical impact of non-invasive delineation of abdominal lymphatic vessels in patients following TCPC with T2 weighted MRI.Scientific reports · 2024Article
- Mitochondrial dysfunction is associated with the severity of liver fibrosis in patients after the Fontan operation.Journal of cellular and molecular medicine · 2024Article
- Fontan-associated liver disease: Diagnosis, surveillance, and management.Frontiers in pediatrics · 2023Review
- Non-invasive assessment of liver abnormalities in pediatric Fontan patients.European journal of pediatrics · 2022Article
- Screening modalities for the diagnosis of Fontan-associated liver disease: evidence from the past for future development.American journal of translational research · 2022Review
- Impact of liver fibrosis and nodules formation on hemodynamics in young adults after total cavopulmonary connection. A magnetic resonance study.Frontiers in cardiovascular medicine · 2022Article
- Heart Rate Variability and Its Associations with Organ Complications in Adults after Fontan Operation.Journal of clinical medicine · 2021Article
- Hepatic Changes in the Fontan Circulation: Identification of Liver Dysfunction and an Attempt to Streamline Follow-up Screening.Pediatric cardiology · 2018Article
- Assessment of Advanced Liver Fibrosis and the Risk for Hepatic Decompensation in Patients With Congestive Hepatopathy.Hepatology (Baltimore, Md.) · 2018Review
- Non-cardiac comorbidities in adults with inherited and congenital heart disease: report from a single center experience of more than 800 consecutive patients.Cardiovascular diagnosis and therapy · 2018Article
- Congestive hepatopathy: Differentiating congestion from fibrosis.Clinical liver disease · 2017Review
- Fontan Liver Disease: Review of an Emerging Epidemic and Management Options.Current treatment options in cardiovascular medicine · 2015Article
- MR assessment of abdominal circulation in Fontan physiology.The international journal of cardiovascular imaging · 2014Review
- Serum hyaluronic acid concentration in Fontan circulation: correlation with hepatic function and portal vein hemodynamics.Pediatric cardiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moderate persistent elevation of the γ-glutamyltransferase (γGT) level is a frequent finding during long-term follow-up of patients with total cavopulmonary connection (TCPC) for palliation of functionally univentricular hearts. Serial intraindividual data revealed a significant increase in the γGT level within a minimum 4-year interval in more than 80 % of cases. The level of γGT elevation showed a significant correlation to hemodynamic parameters such as systemic ventricular end diastolic pressure and mean pulmonary artery pressure, but did not strongly correlate with duration of follow-up or other liver function parameters, which were less frequent and less impressively deranged. None of the patients had signs of synthetic dysfunction. With increasing postoperative follow-up, abnormalities of sonographic hepatic texture including increased echogenicity, inhomogeneity, or liver surface nodularity were found. All 17 patients with liver surface nodularity had a follow-up period of over 10 years. Structural abnormalities did not correlate with biochemical or hemodynamic parameters. Doppler evaluation revealed inspiratory dependence of hepatic vein flow in more than 90 % as a relevant finding after TCPC; a decrease in portal vein flow velocity was observed in many patients. Since long-term survivors after Fontan procedure are at an increased risk of cardiac hepatopathy and cirrhosis, detailed routine investigation and monitoring of hepatic morphology are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.