ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2013
Development of a multichannel vestibular prosthesis prototype by modification of a commercially available cochlear implant.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation
Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction
Vestibular Implantation in Older Adults
Long Term Outcomes After Vestibular Implantation
Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Binocular 3D otolith-ocular reflexes: responses of chinchillas to prosthetic electrical stimulation targeting the utricle and saccule.Journal of neurophysiology · 2020Article
- Virtual Rhesus Labyrinth Model Predicts Responses to Electrical Stimulation Delivered by a Vestibular Prosthesis.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Nonhuman primate vestibuloocular reflex responses to prosthetic vestibular stimulation are robust to pulse timing errors caused by temporal discretization.Journal of neurophysiology · 2019Article
- Implantable Direct Current Neural Modulation: Theory, Feasibility, and Efficacy.Frontiers in neuroscience · 2019Review
- Neurocognitive factors in sensory restoration of early deafness: a connectome model.The Lancet. Neurology · 2016Review
- A CMOS Neural Interface for a Multichannel Vestibular Prosthesis.IEEE transactions on biomedical circuits and systems · 2016Article
- Vestibular implantation and longitudinal electrical stimulation of the semicircular canal afferents in human subjects.Journal of neurophysiology · 2015Article
- Advances in the diagnosis and treatment of vestibular disorders: psychophysics and prosthetics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Review
- Longitudinal performance of an implantable vestibular prosthesis.Hearing research · 2015Article
- Bio-inspired micro-fluidic angular-rate sensor for vestibular prostheses.Sensors (Basel, Switzerland) · 2014Article
- Bilateral Vestibular Deficiency: Quality of Life and Economic Implications.JAMA otolaryngology-- head & neck surgery · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
No adequate treatment exists for individuals who remain disabled by bilateral loss of vestibular (inner ear inertial) sensation despite rehabilitation. We have restored vestibular reflexes using lab-built multichannel vestibular prostheses (MVPs) in animals, but translation to clinical practice may be best accomplished by modification of a commercially available cochlear implant (CI). In this interim report, we describe preliminary efforts toward that goal. We developed software and circuitry to sense head rotation and drive a CI's implanted stimulator (IS) to deliver up to 1 K pulses/s via nine electrodes implanted near vestibular nerve branches. Studies in two rhesus monkeys using the modified CI revealed in vivo performance similar to our existing dedicated MVPs. A key focus of our study was the head-worn unit (HWU), which magnetically couples across the scalp to the IS. The HWU must remain securely fixed to the skull to faithfully sense head motion and maintain continuous stimulation. We measured normal and shear force thresholds at which HWU-IS decoupling occurred as a function of scalp thickness and calculated pressure exerted on the scalp. The HWU remained attached for human scalp thicknesses from 3-7.8 mm for forces experienced during routine daily activities, while pressure on the scalp remained below capillary perfusion pressure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.