ArticleInfection and immunity2013
Redox balance via lactate dehydrogenase is important for multiple stress resistance and virulence in Enterococcus faecalis.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- L-fucose-dependent biofilm formation byBiofilm · 2026Article
- Beyond probiotics and pathobionts: mechanistic roles of enterococcus-derived bioactive components in health and disease.Folia microbiologica · 2026Review
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- Genome-wide analysis ofJournal of bacteriology · 2025Article
- Lactate dehydrogenase is the Achilles' heel of Lyme disease bacteriumbioRxiv : the preprint server for biology · 2025Article
- Metabolic changes inmBio · 2024Article
- Metabolic changes to host cells withbioRxiv : the preprint server for biology · 2023Article
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- Ciprofloxacin-Loaded Gold Nanoparticles against Antimicrobial Resistance: An In Vivo Assessment.Nanomaterials (Basel, Switzerland) · 2021Article
- Hexabromocyclododecanes Are Dehalogenated by CYP168A1 fromApplied and environmental microbiology · 2021Article
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- Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs.Nanomaterials (Basel, Switzerland) · 2020Article
- Metabolic Shift of an Isogenic Strain ofInternational journal of molecular sciences · 2020Article
- Article
- Review
- Substance P enhances lactic acid and tyramine production inGut pathogens · 2017Article
- Prognosis Biomarkers of Severe Sepsis and Septic Shock by 1H NMR Urine Metabolomics in the Intensive Care Unit.PloS one · 2015Article
- The Intraperitoneal Transcriptome of the Opportunistic Pathogen Enterococcus faecalis in Mice.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different environmental stresses depends on the ability of E. faecalis to maintain redox balance via lactate dehydrogenase (LDH). Furthermore, LDH-deficient mutants are less successful than the wild type at colonizing host organs in a murine model of systemic infection. Taken together, our results, as well as those previously published for Staphylococcus aureus (A. R. Richardson, S. J. Libby, and F. C. Fang, Science 319:1672-1676, 2008), identify LDH as an attractive drug target. These drugs may have additional applications, as in the fight against glycopeptide antibiotic-resistant bacteria and even cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.