ArticleInfection and immunity2013
Hypoxia-inducible factor 1-regulated lysyl oxidase is involved in Staphylococcus aureus abscess formation.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Roles of endothelial cells during infection.Current opinion in immunology · 2025Review
- Insight into the research frontier of hypoxia in skin health and diseases: a bibliometric analysis.Annals of medicine and surgery (2012) · 2025Review
- Exploring the relationship between sepsis and Golgi apparatus dysfunction: bioinformatics insights and diagnostic marker discovery.Frontiers in genetics · 2025Article
- Process-Specific Blood Biomarkers and Outcomes in COVID-19 Versus Non-COVID-19 ARDS (APEL-COVID Study): A Prospective, Observational Cohort Study.Journal of clinical medicine · 2024Article
- Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics-a narrative review.Critical care (London, England) · 2024Review
- Gefitinib Results in Robust Host-Directed Immunity AgainstFrontiers in immunology · 2021Article
- The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils andInternational journal of molecular sciences · 2019Review
- Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB.Oncogenesis · 2019Article
- Enhanced pathogenicity of low-pathogenic H9N2 avian influenza virus after vaccination with infectious bronchitis live attenuated vaccine.Veterinary world · 2018Article
- HIF-1alpha and infectious diseases: a new frontier for the development of new therapies.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Review
- Hyper IgE Syndrome and Renal Cell Carcinoma.Case reports in urology · 2017Article
- P-selectin-mediated LOX expression promotes insulinoma growth in Rip1-Tag2 mice by increasing tissue stiffness.International journal of biological sciences · 2016Article
- A novel activation mechanism of avian influenza virus H9N2 by furin.Journal of virology · 2014Article
- Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer.PloS one · 2014Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Hypoxia-inducible factor 1 (HIF-1) is the key transcription factor involved in the adaptation of mammals to hypoxia and plays a crucial role in cancer angiogenesis. Recent evidence suggests a leading role for HIF-1 in various inflammatory and infectious diseases. Here we describe the role of HIF-1 in Staphylococcus aureus infections by investigating the HIF-1-dependent host cell response. For this purpose, transcriptional profiling of HIF-1α-deficient HepG2 and control cells, both infected with Staphylococcus aureus, was performed. Four hours after infection, the expression of 190 genes, 24 of which were regulated via HIF-1, was influenced. LOX (encoding lysyl oxidase) was one of the upregulated genes with a potential impact on the course of S. aureus infection. LOX is an amine oxidase required for biosynthetic cross-linking of extracellular matrix components. LOX was upregulated in vitro in different cell cultures infected with S. aureus and also in vivo, in kidney abscesses of mice intravenously infected with S. aureus and in clinical skin samples from patients with S. aureus infections. Inhibition of LOX by β-aminopropionitrile (BAPN) did not affect the bacterial load in kidneys or blood but significantly influenced abscess morphology and collagenization. Our data provide evidence for a crucial role of HIF-1-regulated LOX in abscess formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.