ArticleNeuroImage2013
Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Multimodal age-dependent diffusion-MRI analysis of the neocortex in a rat model of cortical dysplasia.Scientific reports · 2026Article
- Developmental and regional dependence of macromolecular proton fraction and fractional anisotropy in fixed brain tissue.NMR in biomedicine · 2023Article
- Tissue optimization strategies for high-quality ex vivo diffusion imaging.NMR in biomedicine · 2023Article
- Seeking the Amygdala: Novel Use of Diffusion Tensor Imaging to Delineate the Basolateral Amygdala.Biomedicines · 2023Article
- Brain structure and working memory adaptations associated with maturation and aging in mice.Frontiers in aging neuroscience · 2023Article
- An in vivo accelerated developmental myelination model for testing promyelinating therapeutics.BMC neuroscience · 2022Article
- Multimodal Neuroimaging in Rett Syndrome WithFrontiers in neurology · 2022Review
- A multicontrast MR atlas of the Wistar rat brain.NeuroImage · 2021Article
- Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects.Molecular neurobiology · 2020Article
- Postnatal Guinea Pig Brain Development, as Revealed by Magnetic Resonance and Diffusion Kurtosis Imaging.Brain sciences · 2020Article
- In vivo high-resolution diffusion tensor imaging of the developing neonatal rat cortex and its relationship to glial and dendritic maturation.Brain structure & function · 2019Article
- Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension.PloS one · 2017Article
- A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Functional correlates of central white matter maturation in perinatal period in rabbits.Experimental neurology · 2014Article
- Diffusion tensor imaging reveals white matter injury in a rat model of repetitive blast-induced traumatic brain injury.Journal of neurotrauma · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The postnatal period is a remarkably dynamic phase of brain growth and development characterized by large-scale macrostructural changes, as well as dramatic microstructural changes, including myelination and cortical layering. This crucial period of neurodevelopment is uniquely susceptible to a wide variety of insults that may lead to neurologic disease. MRI is an important tool for studying both normal and abnormal neurodevelopmental changes, and quantitative imaging strategies like diffusion tensor imaging (DTI) allow visualization of many of the complex microstructural changes that occur during postnatal life. Diffusion tensor magnetic resonance histology (DT-MRH) provides particularly unique insight into cytoarchitectural changes in the developing brain. In this study, we used DT-MRH to track microstructural changes in the rat brain throughout normal postnatal neurodevelopment. We provide examples of diffusion tensor parameter changes in both white matter and gray matter structures, and correlate these changes with changes in cytoarchitecture. Finally, we provide a comprehensive database of image sets as a foundation for future studies using DT-MRH to characterize abnormal neurodevelopment in rodent models of neurodevelopmental disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.