ArticleNeuroImage2013
Functional MRI and neural responses in a rat model of Alzheimer's disease.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Hemodynamic and neuronal contributions to low-frequency vascular oscillations in a preclinical model of Alzheimer's disease.Neurophotonics · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Computing hemodynamic response functions from concurrent spectral fiber-photometry and fMRI data.Neurophotonics · 2022Article
- The current status and trend of the functional magnetic resonance combined with stimulation in animals.Frontiers in neuroscience · 2022Article
- Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations.PloS one · 2022Article
- Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis.International journal of molecular sciences · 2021Review
- A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.NeuroImage · 2020Article
- Effects of Hemodynamic Response Function Selection on Rat fMRI Statistical Analyses.Frontiers in neuroscience · 2019Article
- Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer's Disease Phenotype in iPSC Derived Human Neurons.ACS chemical neuroscience · 2018Article
- A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models.Disease models & mechanisms · 2018Review
- Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood.Addiction biology · 2018Article
- Mathematical analysis of the influence of brain metabolism on the BOLD signal in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Metabolic demands of neural-hemodynamic associated and disassociated areas in brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer's disease.Neurophotonics · 2015Article
- The power of using functional fMRI on small rodents to study brain pharmacology and disease.Frontiers in pharmacology · 2015Review
- DYNAmic Multi-coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7 T.NMR in biomedicine · 2014Article
- Contributions and complexities from the use of in vivo animal models to improve understanding of human neuroimaging signals.Frontiers in neuroscience · 2014Review
- Imaging of cerebrovascular pathology in animal models of Alzheimer's disease.Frontiers in aging neuroscience · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Based on the hypothesis that brain plaques and tangles can affect cortical function in Alzheimer's disease (AD), we investigated functional responses in an AD rat model (called the Samaritan Alzheimer's rat achieved by ventricular infusion of amyloid peptide) and age-matched healthy control. High-field functional magnetic resonance imaging (fMRI) and extracellular neural activity measurements were applied to characterize sensory-evoked responses. Electrical stimulation of the forepaw led to BOLD and neural responses in the contralateral somatosensory cortex and thalamus. In AD brain we noted much smaller BOLD activation patterns in the somatosensory cortex (i.e., about 50% less activated voxels compared to normal brain). While magnitudes of BOLD and neural responses in the cerebral cortex were markedly attenuated in AD rats compared to normal rats (by about 50%), the dynamic coupling between the BOLD and neural responses in the cerebral cortex, as assessed by transfer function analysis, remained unaltered between the groups. However thalamic BOLD and neural responses were unaltered in AD brain compared to controls. Thus cortical responses in the AD model were indeed diminished compared to controls, but the thalamic responses in the AD and control rats were quite similar. Therefore these results suggest that Alzheimer's disease may affect cortical function more than subcortical function, which may have implications for interpreting altered human brain functional responses in fMRI studies of Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.