ReviewChest2013
Genetic and immunologic aspects of sleep and sleep disorders.
Review in Chest, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Integrating the precision, sleep, and aerospace medicine fields: a systematic review of the genetic predisposition for obstructive sleep apnea in military aviation.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Within-person associations of daily activity to sleep actigraphy following trauma: Explicating a novel index of risk for major depressive disorder and posttraumatic stress disorder.Journal of psychopathology and clinical science · 2025Article
- Clock-Sleep Communication.Current molecular medicine · 2025Review
- Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea.International journal of impotence research · 2024Article
- Waking Up the Sleep Field: An Overview on the Implications of Genetics and Bioinformatics of Sleep.Molecular biotechnology · 2024Review
- BDNF and proBDNF Serum Protein Levels in Obstructive Sleep Apnea Patients and Their Involvement in Insomnia and Depression Symptoms.Journal of clinical medicine · 2022Article
- Periodic limb movements during sleep: a narrative review.Journal of thoracic disease · 2021Review
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- Family aggregation of sleep characteristics: Results of the Heinz Nixdorf Recall and the Multi-Generation Study.PloS one · 2021Article
- Social-biological influences on sleep duration among adult residents of Northeastern China.Health and quality of life outcomes · 2019Article
- The social evolution of sleep: sex differences, intragenomic conflicts and clinical pathologies.Proceedings. Biological sciences · 2019Article
- Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.International journal of molecular epidemiology and genetics · 2019Article
- Understanding Pathophysiological Concepts Leading to Obstructive Apnea.Obesity surgery · 2018Review
- Dad's Snoring May Have Left Molecular Scars in Your DNA: the Emerging Role of Epigenetics in Sleep Disorders.Molecular neurobiology · 2018Review
- How does healthy aging impact on the circadian clock?Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth.Epigenetics · 2014Article
- Fighting insomnia and battling lethargy: the yin and yang of palliative care.Current oncology reports · 2014Review
- Brown Norway and Zucker Lean rats demonstrate circadian variation in ventilation and sleep apnea.Sleep · 2014Article
- Prevalence of periodical leg movements in patients with narcolepsy in an outpatient facility in São Paulo.Sleep science (Sao Paulo, Brazil) · 2014Article
- Bioenergy and its Implication for Yoga Therapy.International journal of yogaArticle
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of genetics is providing new and exciting insights into the pathogenesis, diagnosis, and treatment of disease. Both normal sleep and several types of sleep disturbances have been found to have significant genetic influences, as have traits of normal sleep, such as those evident in EEG patterns and the circadian sleep-wake cycle. The circadian sleep-wake cycle is based on a complex feedback loop of genetic transcription over a 24-h cycle. Restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) have familial aggregation, and several genes have a strong association with them. Recent genome-wide association studies have identified single nucleotide polymorphisms linked to RLS/PLMS, although none has a definite functional correlation. Narcolepsy/cataplexy are associated with HLA DQB1*0602 and a T-cell receptor α locus, although functional correlations have not been evident. Obstructive sleep apnea is a complex disorder involving multiple traits, such as anatomy of the oropharynx, ventilatory control, and traits associated with obesity. Although there is clear evidence of familial aggregation in the obstructive sleep apnea syndrome, no specific gene or locus has been identified for it. Angiotensin-converting enzyme has been proposed as a risk variant, but evidence is weak. Fatal familial insomnia and advanced sleep phase syndrome are sleep disorders with a definite genetic basis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.