ArticleNeuroscience and biobehavioral reviews2013
Intranasal administration of oxytocin: behavioral and clinical effects, a review.
Article in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02526914 (Effects of Intranasal Oxytocin and Vasopressin on Social Behavior and Decision Making), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Intranasal Oxytocin and Vasopressin on Social Behavior and Decision Making
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- A Systematic Review of Primary and Secondary Callous-Unemotional Traits and Psychopathy Variants in Youth.Clinical child and family psychology review · 2021Pooled it
- The Role of Oxytocin in Antisocial Personality Disorders: A Systematic Review of the Literature.Frontiers in psychiatry · 2019Pooled it
- Intranasal oxytocin modulates brain activity during emotional processing in children with treatment resistant conduct problems.Scientific reports · 2025Trial
- A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome.Molecular autism · 2021Trial
- The role of oxytocin in delay of gratification and flexibility in non-social decision making.eLife · 2021Trial
- Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial.Molecular psychiatry · 2015Trial
- Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study.PloS one · 2015Trial
- Oxytocin administration enhances controlled social cognition in patients with schizophrenia.Psychoneuroendocrinology · 2014Trial
- A Preliminary Examination of Endogenous Peripheral Oxytocin in a Pilot Randomized Clinical Trial of Oxytocin-Enhanced Psychotherapy for Posttraumatic Stress Disorder.Journal of clinical psychopharmacologyTrial
- Endogenous oxytocin-linked heart-rate synchrony and social connection during live sports spectatorship.Translational psychiatry · 2026Article
- Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex.Science advances · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Oxytocin in the Amygdala Sustains Prosocial Behavior via State-Dependent Amygdala-Prefrontal Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Oxytocin Reduces Noradrenergic-Induced Opioid-Like Withdrawal Symptoms in Individuals on Opioid Agonist Therapy.Biological psychiatry global open science · 2025Article
- Oxytocin in neurodevelopmental disorders: Autism spectrum disorder and Prader-Willi syndrome.Pharmacology & therapeutics · 2024Review
- Oxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Brain sciences · 2024Article
- Induction of nitric oxide via humming does not improve short-term cognitive performance or influence emotional processing.PloS one · 2024Article
- Oxytocin measurements in saliva: an analytical perspective.BMC veterinary research · 2023Review
- Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice.iScience · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intranasal (IN-) administration of substances is attracting attention from scientists as well as pharmaceutical companies. The effects are surprisingly fast and specific. The present review explores our current knowledge about the routes of access to the cranial cavity. 'Direct-access-pathways' from the nasal cavity have been described but many additional experiments are needed to answer a variety of open questions regarding anatomy and physiology. Among the IN-applied substances oxytocin (OT) has an extensive history. Originally applied in women for its physiological effects related to lactation and parturition, over the last decade most studies focused on their behavioral 'prosocial' effects: from social relations and 'trust' to treatment of 'autism'. Only very recently in a microdialysis study in rats and mice, the 'direct-nose-brain-pathways' of IN-OT have been investigated directly, implying that we are strongly dependent on results obtained from other IN-applied substances. Especially the possibility that IN-OT activates the 'intrinsic' OT-system in the hypothalamus as well needs further clarification. We conclude that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.