Evidence map›Paper›PMID 23648426›Full record

ReviewInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2014

Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus.

Anne-Catrin Uhlemann, Michael Otto, Franklin D Lowy, Frank R DeLeo

Abstract readReview
In one paragraph

Review in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

  1. Article
  2. Genomic diversity and topical antimicrobial resistance inAntimicrobial agents and chemotherapy · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Antibiotics (Basel, Switzerland) · 2025
    Review
  9. Methicillin-sensitiveMicrobial genomics · 2025
    Article
  10. Review
  11. Urinary tract infections and catheter-associated urinary tract infections caused byMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  12. Clonal distribution and molecular characterization ofMedicine and pharmacy reports · 2024
    Article
  13. Article
  14. mLife · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Draft genome sequence of a highly proteolyticMicrobiology resource announcements · 2023
    Article
  20. Community-Acquired Methicillin-ResistantDiagnostics (Basel, Switzerland) · 2023
    Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anne-Catrin UhlemannDivision of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Michael OttoLaboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Franklin D LowyDivision of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Frank R DeLeoLaboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Electronic address: fdeleo@niaid.nih.gov.

Funding

Staphylococcal pathogenesisZIAAI000904 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OTTO, MICHAEL · 2009 to 2025
$22.6M
Mechanisms of Staphylococcus aureus virulenceZIAAI001079 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DELEO, FRANK · 2009 to 2025
$11.8M
Modeling of S.Aureus Transmission in Northern ManhattanR01AI077690 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOWY, FRANKLIN D · 2009 to 2013
$3.4M
Mechanisms of S. aureus transmission and persistence.K08AI090013 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2010 to 2014
$655k
Intramural NIH HHS ZIA AI001079NIAID NIH HHS K08 AI090013NIAID NIH HHS R01 AI077690
6 · The paper itself

Abstract

Staphylococcus aureus is a prominent cause of human infections globally. The high prevalence of infections is compounded by antibiotic resistance--a significant problem for treatment. Methicillin-resistant S. aureus (MRSA) is endemic in hospitals and healthcare facilities worldwide, and is an increasingly common cause of community-associated bacterial infections in industrialized countries. Although much focus is placed on the role of S. aureus as a human pathogen, it is in fact a human commensal organism that has had a relatively long coexistence with the human host. Many S. aureus infections can be explained by host susceptibility or other predisposing risk factors. On the other hand, the emergence/re-emergence of successful S. aureus clones (referred to as epidemic waves) suggests a rapid bacterial adaption and evolution, which includes the emergence of antibiotic resistance and increased virulence and/or transmissibility. It is within this context that we review our understanding of selected S. aureus epidemic waves, and highlight the use of genome sequencing as a means to better understand the evolution of each lineage.

Indexed as

Community-Acquired InfectionsEvolution, MolecularGenome, BacterialHumansMethicillin-Resistant Staphylococcus aureusPhylogenySequence Analysis, DNAStaphylococcal InfectionsVirulence FactorsVirulence FactorsAntimicrobial resistanceEpidemicGenome sequencingMRSAStaphylococcus aureus

Identifiers

PMID23648426
PMCPMC3884050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.