Evidence map›Paper›PMID 23648395›Full record

Trial reportContemporary clinical trials2013

DASH for asthma: a pilot study of the DASH diet in not-well-controlled adult asthma.

Jun Ma, Peg Strub, Phillip W Lavori, A Sonia Buist, Carlos A Camargo, Kari C Nadeau, Sandra R Wilson, Lan Xiao

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Contemporary clinical trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Vitamins C and E for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2014
    Pooled it
  3. Vitamin C for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2013
    Pooled it
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  14. Article
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  18. Association between Western diet pattern and adult asthma: a focused review.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jun MaDepartment of Health Services Research, Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA. maj@pamfri.org
Peg Strub
Phillip W Lavori
A Sonia Buist
Carlos A Camargo
Kari C Nadeau
Sandra R Wilson
Lan Xiao
Stanford University · USMassachusetts General Hospital · USOregon Health & Science University · USPalo Alto Medical Foundation · US

Funding

SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0M
A Pilot Study of the DASH Diet in Not-Well-Controlled Adult AsthmaR34HL108753 · NHLBI · PALO ALTO MEDICAL FOUNDATION RES INST · PI MA, JUN · 2012 to 2013
$691k
Development of Improved Diagnostic Allergy TestR21AI095838 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2011 to 2012
$435k
NHLBI NIH HHS R34 HL108753NIAID NIH HHS R21 AI095838NIAID NIH HHS U01 AI147462
6 · The paper itself

Abstract

This pilot study aims to provide effect size confidence intervals, clinical trial and intervention feasibility data, and procedural materials for a full-scale randomized controlled trial that will determine the efficacy of Dietary Approaches to Stop Hypertension (DASH) as adjunct therapy to standard care for adults with uncontrolled asthma. The DASH diet encompasses foods (e.g., fresh fruit, vegetables, and nuts) and antioxidant nutrients (e.g., vitamins A, C, E, and zinc) with potential benefits for persons with asthma, but it is unknown whether the whole diet is beneficial. Participants (n = 90) will be randomized to receive usual care alone or combined with a DASH intervention consisting of 8 group and 3 individual sessions during the first 3 months, followed by at least monthly phone consultations for another 3 months. Follow-up assessments will occur at 3 and 6 months. The primary outcome measure is the 7-item Juniper Asthma Control Questionnaire, a validated composite measure of daytime and nocturnal symptoms, activity limitations, rescue medication use, and percentage predicted forced expiratory volume in 1 second. We will explore changes in inflammatory markers important to asthma pathophysiology (e.g., fractional exhaled nitric oxide) and their potential to mediate the intervention effect on disease control. We will also conduct pre-specified subgroup analyses by genotype (e.g., polymorphisms on the glutathione S transferase gene) and phenotype (e.g., atopy, obesity). By evaluating a dietary pattern approach to improving asthma control, this study could advance the evidence base for refining clinical guidelines and public health recommendations regarding the role of dietary modifications in asthma management.

Indexed as

AdolescentAdultAgedAsthmaFeasibility StudiesFemaleHumansHypertensionMaleMiddle AgedPilot ProjectsSpirometryTreatment OutcomeYoung AdultACQAsthmaAsthma Control QuestionnaireCIconfidence intervalDASHDietary Approaches to Stop HypertensionDietary patternFeNOFEV1forced expiratory volume in one secondfractional exhaled nitric oxideKaiser PermanenteKPLung functionPCPprimary care provider.

Identifiers

PMID23648395
PMCPMC4217513
OpenAlexW2010248946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.