ReviewMutation research
Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents.
Review in Mutation research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02566161 (Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study)
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Somatic health effects of Chernobyl: 30 years on.European journal of epidemiology · 2017Pooled it
- Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans.Scientific reports · 2025Article
- A Review: Multi-Omics Approach to Studying the Association between Ionizing Radiation Effects on Biological Aging.Biology · 2024Review
- High Resolution and Automatable Cytogenetic Biodosimetry Using In Situ Telomere and Centromere Hybridization for the Accurate Detection of DNA Damage: An Overview.International journal of molecular sciences · 2023Review
- Article
- No evidence of increased mutations in the germline of a group of British nuclear test veterans.Scientific reports · 2022Article
- Review
- Congenital Malformations and Perinatal Deaths Among the Children of Atomic Bomb Survivors: A Reappraisal.American journal of epidemiology · 2021Article
- Yamada et al. Respond to "Radiation and Reproductive Health".American journal of epidemiology · 2021Article
- Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident.Science (New York, N.Y.) · 2021Article
- Disproportionate Impacts of Radiation Exposure on Women, Children, and Pregnancy: Taking Back our Narrative.Journal of the history of biology · 2021Article
- Field Study of the Possible Effect of Parental Irradiation on the Germline of Children Born to Cleanup Workers and Evacuees of the Chornobyl Nuclear Accident.American journal of epidemiology · 2020Article
- The Likelihood of Adverse Pregnancy Outcomes and Genetic Disease (Transgenerational Effects) from Exposure to Radioactive Fallout from the 1945 Trinity Atomic Bomb Test.Health physics · 2020Article
- Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.International journal of molecular sciences · 2020Review
- Reproductive Effects of Exposure to Low-Dose Ionizing Radiation: A Long-Term Follow-Up of Immigrant Women Exposed to the Chernobyl Accident.Journal of clinical medicine · 2020Article
- Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes.Scientific reports · 2020Article
- Increased Transgenerational Intestinal Tumorigenesis in Offspring of Ionizing Radiation Exposed Parent APCJournal of Cancer · 2017Article
- Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn Ptch1⁺/⁻ mice after paternal irradiation.Oncotarget · 2015Article
- Parental age affects somatic mutation rates in the progeny of flowering plants.Plant physiology · 2015Article
- Task-based measures of image quality and their relation to radiation dose and patient risk.Physics in medicine and biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In this article we review health effects in offspring of human populations exposed as a result of radiotherapy and some groups exposed to chemotherapy. We also assess risks in offspring of other radiation-exposed groups, in particular those of the Japanese atomic bomb survivors and occupationally and environmentally exposed groups. Experimental findings are also briefly surveyed. Animal and cellular studies tend to suggest that the irradiation of males, at least at high doses (mostly 1Gy and above), can lead to observable effects (including both genetic and epigenetic) in the somatic cells of their offspring over several generations that are not attributable to the inheritance of a simple mutation through the parental germline. However, studies of disease in the offspring of irradiated humans have not identified any effects on health. The available evidence therefore suggests that human health has not been significantly affected by transgenerational effects of radiation. It is possible that transgenerational effects are restricted to relatively short times post-exposure and in humans conception at short times after exposure is likely to be rare. Further research that may help resolve the apparent discrepancies between cellular/animal studies and studies of human health are outlined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.