ArticleEmerging infectious diseases2013
Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.
Article in Emerging infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Effects of MAO-A and CYP450 on primaquine metabolism in healthy volunteers.Parasitology research · 2019Trial
- Article
- PvGTSeq and PvCRiSP: Two amplicon-based targeted sequencing panels for Plasmodium vivax.PLoS neglected tropical diseases · 2026Article
- Quest for malaria management using natural remedies.Frontiers in pharmacology · 2024Review
- Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria.Biology · 2022Review
- Novel highly-multiplexed AmpliSeq targeted assay forFrontiers in cellular and infection microbiology · 2022Article
- A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria.PLoS genetics · 2020Article
- The genomic architecture of antimalarial drug resistance.Briefings in functional genomics · 2019Review
- Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor.Malaria journal · 2019Article
- A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax.Malaria journal · 2018Article
- Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes.Malaria journal · 2017Article
- High Efficacy of Primaquine Treatment for Plasmodium vivax in Western Thailand.The American journal of tropical medicine and hygiene · 2016Article
- A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP1Scientific reports · 2016Article
- Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections.Malaria journal · 2016Article
- Repeated Plasmodium vivax malaria relapses in a Peruvian sailor.Malaria journal · 2015Article
- Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.Pathogens and global health · 2015Review
- Emerging Plasmodium vivax resistance to chloroquine in South America: an overview.Memorias do Instituto Oswaldo Cruz · 2014Review
- A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings.PLoS neglected tropical diseases · 2014Article
- Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.Malaria journal · 2014Article
- Antimalarial drug discovery - approaches and progress towards new medicines.Nature reviews. Microbiology · 2013Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.