Evidence map›Paper›PMID 23647971›Full record

ReviewCurrent opinion in biotechnology2013

Quantitative approaches to uncover physical mechanisms of tissue morphogenesis.

Jason P Gleghorn, Sriram Manivannan, Celeste M Nelson

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A toolbox to explore the mechanics of living embryonic tissues.Seminars in cell & developmental biology · 2016
    Review
  7. Fast nastic motion of plants and bioinspired structures.Journal of the Royal Society, Interface · 2015
    Review
  8. Cellular and physical mechanisms of branching morphogenesis.Development (Cambridge, England) · 2014
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jason P GleghornDepartment of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Sriram Manivannan
Celeste M Nelson

Funding

Spatial patterning of branching morphogenesisR01GM083997 · NIGMS · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2008 to 2012
$1.4M
Mechanical regulation of branching morphogenesisR21HL110335 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2011 to 2012
$443k
NHLBI NIH HHS HL110335NHLBI NIH HHS R21 HL110335NIGMS NIH HHS GM083997NIGMS NIH HHS R01 GM083997
6 · The paper itself

Abstract

Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.

Indexed as

Cell Physiological PhenomenaComputer SimulationMorphogenesisAnimalsBiomechanical PhenomenaCell TrackingModels, BiologicalTime Factors

Identifiers

PMID23647971
PMCPMC3762917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.