Evidence map›Paper›PMID 23647796›Full record

ArticleJACC. Cardiovascular imaging2013

Proximal superficial femoral artery occlusion, collateral vessels, and walking performance in peripheral artery disease.

Mary M McDermott, Timothy J Carroll, Melina Kibbe, Christopher M Kramer, Kiang Liu, Jack M Guralnik, Aoife N Keeling, Michael H Criqui, Luigi Ferrucci, Chun Yuan and 5 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in JACC. Cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00520312 (Magnetic Resonance in Peripheral Arterial Disease), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00520312 completednot on this map

Magnetic Resonance in Peripheral Arterial Disease

TypeobservationalSponsorNorthwestern UniversityRan2007 to 2012Enrolled519ConditionsPeripheral Vascular Diseases
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Peripheral artery disease.Nature reviews. Disease primers · 2025
    Review
  3. Clinical outcomes of acute limb ischaemia caused by femoropopliteal stent thrombosis.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Article
  18. Discrepancies in Prevalence of Peripheral Arterial Disease between Lower Extremities at Rest and Postexercise.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Mary M McDermottDepartment of Medicine, Northwestern University's Feinberg School of Medicine, Chicago, IL 60611, USA. dm608@northwestern.edu
Timothy J Carroll
Melina Kibbe
Christopher M Kramer
Kiang Liu
Jack M Guralnik
Aoife N Keeling
Michael H Criqui
Luigi Ferrucci
Chun Yuan
Lu Tian
Yihua Liao
Jarett Berry
Lihui Zhao
James Carr
Northwestern University · USBeaumont Hospital · IENational Institute on Aging · USStanford University · USThe University of Texas Southwestern Medical Center · USUniversity of California San Diego · USUniversity of Maryland, Baltimore · USUniversity of Virginia · USUniversity of Washington · US

Funding

Comprehensive Magnetic Resonance in PADR01HL075792 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRAMER, CHRISTOPHER M. · 2003 to 2021
$10.5M
Magnetic Resonance in Peripheral Arterial DiseaseR01HL083064 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCDERMOTT, MARY MCGRAE · 2007 to 2010
$2.9M
Femoral Plaque Composition, Oxidative Stress, and Coronary EventsR01HL109244 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCDERMOTT, MARY MCGRAE · 2011 to 2014
$2.7M
Intramural NIH HHSNHLBI NIH HHS R01 HL075792NHLBI NIH HHS R01 HL083064NHLBI NIH HHS R01-HL083064NHLBI NIH HHS R01 HL109244NHLBI NIH HHS R01-HL109244
6 · The paper itself

Abstract

objectivesWe studied associations of magnetic resonance imaging (MRI)-measured superficial femoral artery (SFA) occlusions with functional performance, leg symptoms, and collateral vessel number in peripheral artery disease (PAD). We studied associations of collateral vessel number with functional performance in PAD.

backgroundAssociations of MRI-detected SFA occlusion and collateral vessel number with functional performance among individuals with PAD have not been reported.

methodsA total of 457 participants with an ankle brachial index (ABI) <1.00 had MRI measurement of the proximal SFA with 12 consecutive 2.5-μm cross-sectional images. An occluded SFA was defined as an SFA in which at least 1 segment was occluded. A nonoccluded SFA was defined as absence of any occluded slices. Collateral vessels were visualized with magnetic resonance angiography. Lower extremity functional performance was measured with the 6-min walk, 4-m walking velocity at usual and fastest pace, and the Short Physical Performance Battery (SPPB) (0 to 12 scale, 12 = best).

resultsAdjusting for age, sex, race, comorbidities, and other confounders, the presence of an SFA occlusion was associated with poorer 6-min walk performance (1,031 vs. 1,169 feet, p = 0.006), slower fast-paced walking velocity (1.15 vs. 1.22 m/s, p = 0.042), and lower SPPB score (9.07 vs. 9.75, p = 0.038) compared with the absence of an SFA occlusion. More numerous collateral vessels were associated with better 6-min walk performance (0 to 3 collaterals-1,064 feet, 4 to 7 collaterals-1,165 feet, ≥8 collaterals-1,246 feet, p trend = 0.007), faster usual-paced walking speed (0 to 3 collaterals-0.84 m/s, 4 to 7 collaterals-0.88 m/s, ≥8 collaterals-0.91 m/s, p trend = 0.029), and faster rapid-paced walking speed (0 to 3 collaterals-1.17 m/s, 4 to 7 collaterals-1.22 m/s, ≥8 collaterals-1.29 m/s, p trend = 0.002), adjusting for age, sex, race, comorbidities, ABI, and other confounders.

conclusionsAmong PAD participants, MRI-visualized occlusions in the proximal SFA are associated with poorer functional performance, whereas more numerous collaterals are associated with better functional performance. (Magnetic Resonance Imaging to Identify Characteristics of Plaque Build-Up in People With Peripheral Arterial Disease; NCT00520312).

Indexed as

Collateral CirculationWalkingAgedAnalysis of VarianceAnkle Brachial IndexChicagoChi-Square DistributionComorbidityConstriction, PathologicCross-Sectional StudiesExercise TestFemaleFemoral ArteryHumansLogistic ModelsMagnetic Resonance Angiography

Identifiers

PMID23647796
PMCPMC3766720
OpenAlexW2051704920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.