ArticleThe journal of allergy and clinical immunology. In practice2013
Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea.
Article in The journal of allergy and clinical immunology. In practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.The journal of allergy and clinical immunology. In practiceTrial
- Association between relative fat mass and asthma risk in middle-aged and elderly Chinese population: a retrospective cohort study based on the CHARLS database.BMC public health · 2026Observational
- Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea.Respiratory physiology & neurobiology · 2024Article
- Altered Symptom Perception in Children With Asthma Is Associated With Poor Childhood Opportunity and Adverse Outcomes.The journal of allergy and clinical immunology. In practice · 2024Article
- Management of the pediatric patient with asthma and obesity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Obesity-related pediatric asthma: relationships between pulmonary function and clinical outcomes.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Obesity Is Associated with Sustained Symptomatology and Unique Inflammatory Features in Children with Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- Effects of obesity on the oxygen cost of breathing in children.Respiratory physiology & neurobiology · 2021Article
- Associations between overweight and obesity and asthma outcomes in urban adolescents.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Asthma attacks in children are always preceded by poor asthma control: myth or maxim?Breathe (Sheffield, England) · 2020Article
- Pediatric Severe Asthma in the Era of Biologic Treatments.Pediatric allergy, immunology, and pulmonology · 2020Article
- RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Article
- Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management.Expert review of endocrinology & metabolism · 2019Review
- Asthma medication in children who are overweight/obese: justified treatment?BMC pediatrics · 2019Observational
- The Association between Asthma and Obesity in Children - Inflammatory and Mechanical Factors.Open access Macedonian journal of medical sciences · 2019Article
- A Practical Approach to Severe Asthma in Children.Annals of the American Thoracic Society · 2018Review
- Association of exercise-induced wheeze and other asthma symptoms with emergency department visits and hospitalizations in a large cohort of urban adolescents.Respiratory medicine · 2018Article
- Asthma and Obesity: The Chicken, the Egg, or More Than One Beast?American journal of respiratory and critical care medicine · 2017Article
- The effect of obesity, weight gain, and weight loss on asthma inception and control.Current opinion in allergy and clinical immunology · 2017Review
- Physical activity, restrictions in activity, and body mass index among urban children with persistent asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough studies in adults have shown a non-TH2 obese asthma phenotype, whether a similar phenotype exists in children is unclear.
objectiveWe hypothesized that asthmatic children with obesity, defined as a body mass index above the 95th percentile for age and sex, would have poorer asthma control as well as decreased quality of life, increased health care utilization, and decreased pulmonary function measures as a function of increased TH1 versus TH2 polarization.
methodsThis study involved a post hoc analysis of cross sectional data from 269 children 6 to 17 years of age enrolled in the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Children answered questionnaires and underwent spirometry, plethysmography, exhaled nitric oxide determination, and venipuncture for TH1/TH2 cytokine determination. Asthma control was defined according to national asthma treatment guidelines that are based on prespecified thresholds for lung function and symptom frequency.
resultsFifty-eight children (22%) were overweight and 67(25%) were obese. Obese children did not have poorer asthma control but were more likely to report nonspecific symptoms such as dyspnea and nocturnal awakenings. Obese children did have decreased asthma-related quality of life and increased health care utilization, but this was not associated with airflow limitation. Instead, obese children had decreased functional residual capacity. A unique pattern of TH1 or TH2 polarization was not observed.
conclusionsPoor asthma control in obese children with asthma may be overestimated because of enhanced perception of nonspecific symptoms such as dyspnea that results from altered mechanical properties of the chest wall. Careful assessment of physiologic as well as symptom-based measures is needed in the evaluation of obese children with respiratory symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.