ArticlePloS one2013
Host restrictions of avian influenza viruses: in silico analysis of H13 and H16 specific signatures in the internal proteins.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Highly Pathogenic Avian Influenza A (H5N1) Caused Mass Death Among Black-Legged Kittiwakes (Transboundary and emerging diseases · 2026Article
- Highly Pathogenic Clade 2.3.4.4b H5N1 Influenza Virus in Seabirds in France, 2022-2023.Transboundary and emerging diseases · 2025Article
- Article
- Article
- Novel H16N3 avian influenza viruses isolated from migratory gulls in China in 2023.Frontiers in microbiology · 2024Article
- Ecological divergence of wild birds drives avian influenza spillover and global spread.PLoS pathogens · 2022Article
- Characteristics of the first H16N3 subtype influenza A viruses isolated in western China.Transboundary and emerging diseases · 2020Article
- Phylogeography and Antigenic Diversity of Low-Pathogenic Avian Influenza H13 and H16 Viruses.Journal of virology · 2020Article
- Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.Journal of virology · 2019Article
- Phylogeographic evidence for the inter- and intracontinental dissemination of avian influenza viruses via migration flyways.PloS one · 2019Article
- Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species - Support for the Community Concept.Frontiers in microbiology · 2019Article
- Avian Influenza Viruses in Wild Birds: Virus Evolution in a Multihost Ecosystem.Journal of virology · 2018Article
- Failure of productive infection of Mallards (Anas platyrhynchos) with H16 subtype of avian influenza viruses.Influenza and other respiratory viruses · 2014Article
- Molecular characterization and phylogenetics of a reassortant H13N8 influenza virus isolated from gulls in Mongolia.Virus genes · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gulls are the primary hosts of H13 and H16 avian influenza viruses (AIVs). The molecular basis for this host restriction is only partially understood. In this study, amino acid sequences from Eurasian gull H13 and H16 AIVs and Eurasian AIVs (non H13 and H16) were compared to determine if specific signatures are present only in the internal proteins of H13 and H16 AIVs, using a bioinformatics approach. Amino acids identified in an initial analysis performed on 15 selected sequences were checked against a comprehensive set of AIV sequences retrieved from Genbank to verify them as H13 and H16 specific signatures. Analysis of protein similarities and prediction of subcellular localization signals were performed to search for possible functions associated with the confirmed signatures. H13 and H16 AIV specific signatures were found in all the internal proteins examined, but most were found in the non-structural protein 1 (NS1) and in the nucleoprotein. A putative functional signature was predicted to be present in the nuclear export protein. Moreover, it was predicted that the NS1 of H13 and H16 AIVs lack one of the nuclear localization signals present in NS1 of other AIV subtypes. These findings suggest that the signatures found in the internal proteins of H13 and H16 viruses are possibly related to host restriction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.