ArticlePloS one2013
Baicalein reduces airway injury in allergen and IL-13 induced airway inflammation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Efficacy ofNutrients · 2024Trial
- Oxidative stress driven airway mesenchymal reprogramming in asthma: mechanistic insights and evidence from botanical drug formulations.Frontiers in pharmacology · 2026Review
- Targeting mitochondrial function as a potential therapeutic approach for allergic asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Quality evaluation ofFrontiers in pharmacology · 2025Article
- Airway Epithelium: A Neglected but Crucial Cell Type in Asthma Pathobiology.Diagnostics (Basel, Switzerland) · 2023Review
- Edible and Herbal Plants for the Prevention and Management of COVID-19.Frontiers in pharmacology · 2021Review
- Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.Scientific reports · 2019Article
- Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors.Scientific reports · 2019Article
- Role of Leukotriene BInternational journal of molecular sciences · 2019Review
- Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction.Frontiers in pharmacology · 2019Article
- Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.Allergy · 2018Article
- Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR-424-3p and targeting PTEN/PI3K/Akt pathway.Journal of cellular and molecular medicine · 2018Article
- Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review.World journal of gastroenterology · 2017Review
- Baicalein, wogonin, andAnatomy & cell biology · 2017Article
- Baicalein Promotes Neuronal and Behavioral Recovery After Intracerebral Hemorrhage Via Suppressing Apoptosis, Oxidative Stress and Neuroinflammation.Neurochemical research · 2017Article
- Baicalein induces CD4(+)Foxp3(+) T cells and enhances intestinal barrier function in a mouse model of food allergy.Scientific reports · 2016Article
- Biosynthesis of oxidized lipid mediators via lipoprotein-associated phospholipase A2 hydrolysis of extracellular cardiolipin induces endothelial toxicity.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications.Mediators of inflammation · 2016Review
- Obesity, metabolic syndrome, and airway disease: a bioenergetic problem?Immunology and allergy clinics of North America · 2014Review
- In vitro sensitization of erythrocytes to programmed cell death following baicalein treatment.Toxins · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBaicalein, a bioflavone present in the dry roots of Scutellaria baicalensis Georgi, is known to reduce eotaxin production in human fibroblasts. However, there are no reports of its anti-asthma activity or its effect on airway injury. METHODOLOGY/PRINCIPAL
findingsIn a standard experimental asthma model, male Balb/c mice that were sensitized with ovalbumin (OVA), treated with baicalein (10 mg/kg, ip) or a vehicle control, either during (preventive use) or after OVA challenge (therapeutic use). In an alternate model, baicalein was administered to male Balb/c mice which were given either IL-4 or IL-13 intranasally. Features of asthma were determined by estimating airway hyperresponsiveness (AHR), histopathological changes and biochemical assays of key inflammatory molecules. Airway injury was determined with apoptotic assays, transmission electron microscopy and assessing key mitochondrial functions. Baicalein treatment reduced AHR and inflammation in both experimental models. TGF-β₁, sub-epithelial fibrosis and goblet cell metaplasia, were also reduced. Furthermore, baicalein treatment significantly reduced 12/15-LOX activity, features of mitochondrial dysfunctions, and apoptosis of bronchial epithelia. CONCLUSION/SIGNIFICANCE: Our findings demonstrate that baicalein can attenuate important features of asthma, possibly through the reduction of airway injury and restoration of mitochondrial function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.