ArticleClinical Medicine Insights. Cardiology2013
Unique and Varied Contributions of Traditional CVD Risk Factors: A Systematic Literature Review of CAD Risk Factors in China.
Article in Clinical Medicine Insights. Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- Plasma Metabolites Alert Patients With Chest Pain to Occurrence of Myocardial Infarction.Frontiers in cardiovascular medicine · 2021Article
- Association between α1-antitrypsin and acute coronary syndrome.Experimental and therapeutic medicine · 2020Article
- Association of polymorphisms of preptin, irisin and adropin genes with susceptibility to coronary artery disease and hypertension.Medicine · 2020Article
- Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors.Experimental and therapeutic medicine · 2018Article
- Association of rs662799 in APOA5 with CAD in Chinese Han population.BMC cardiovascular disorders · 2018Article
- Association between theInternational journal of clinical and experimental pathology · 2018Article
- Association betweenBiomedical reports · 2014Article
- Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations.Lipids in health and disease · 2014Article
- Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke.Neural regeneration research · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThis study is the first systematic review of risk factors for stroke in China and supports the importance of current public health initiatives to manage the risk factors appropriately to reduce risk of stroke in high risk patients. Additionally, this study has been co-authored by prominent Chinese and US physicians and researchers with expertise in cardiovascular disease, neurologic disorders, epidemiology, and real world data. While there have been several systematic reviews of real world associations of risk factors for coronary artery disease, none focus specifically on the population of China, where there is growing evidence that such risk factors are poorly treated or uncontrolled, especially in rural areas.
backgroundTo better understand the impact of traditional cardiovascular risk factors on risk of coronary artery disease (CAD) in China, a systematic review of all Chinese observational studies published in either English or Chinese in MEDLINE and EMBASE over the last 5 years was performed and the association between any of 5 traditional risk factors (ie, hypertension, diabetes, elevated lipid levels, obesity, and smoking) and the risk of CAD was studied. METHODS AND
resultsThe study found a consistent relationship between lipid levels and CAD. Higher low-density lipoprotein cholesterol values were associated with greater risk of CAD, with an odds ratio as high as 3.31. Other factors found to be significant contributors to the risk of CAD included hypertension (crude odds ratio range of 1.40-5.11), diabetes (1.50-5.97), and smoking (1.37-5.19). An association between obesity and CAD in China was observed, but the evidence supporting this was considered weak due to the paucity of studies found as part of this review.
conclusionsThis review provides a systematic summary of CAD risk factors in China and demonstrates the important differences that exist in CAD risk factors between countries and regions. Approaches to reduce CAD globally must take into account the unique risk factors that drive CAD in each country and region as is demonstrated by these findings.
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