ArticleIranian journal of medical sciences2013
The Antibacterial Activity of Selected Labiatae (Lamiaceae) Essential Oils against Brucella melitensis.
Article in Iranian journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Antibacterial, Synergistic, and Antibiofilm Activities ofAntibiotics (Basel, Switzerland) · 2026Article
- Synergistic Antibacterial Effects of Plant Extracts and Essential Oils Against Drug-Resistant Bacteria of Clinical Interest.Pathogens (Basel, Switzerland) · 2025Article
- Comparison ofJournal of dentistry (Shiraz, Iran) · 2024Article
- Article
- The current therapeutical strategies in human brucellosis.Infection · 2021Review
- Essential Oils of Seven Lamiaceae Plants and Their Antioxidant Capacity.Molecules (Basel, Switzerland) · 2021Article
- Chemical Composition and Bioactivity of Essential Oil of TenMolecules (Basel, Switzerland) · 2020Article
- Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds.Future science OA · 2019Article
- Anti-Brucella activity of Caryopteris mongolica Bunge root extract against Brucella melitensis infection in mice.BMC complementary and alternative medicine · 2018Article
- The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes.PloS one · 2018Article
- Biological Activities of Three Essential Oils of the Lamiaceae Family.Medicines (Basel, Switzerland) · 2017Review
- Microarray-based long oligonucleotides probe designed for Brucella Spp. detection and identification of antibiotic susceptibility pattern.Electronic physician · 2016Article
- Species-specific PCR for the Diagnosis and Determination of Antibiotic Susceptibilities ofIranian journal of pathology · 2016Article
- Prospects for usingJournal of advanced pharmaceutical technology & researchReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrucellosis, a zoonosis caused by four species of brucella, has a high morbidity. The major cause of brucellosis worldwide is brucella melitensis. Medicinal plants are considered as new antibacterial sources that could replace conventional antibiotics in the treatment of antibiotic-resistant bacteria. The aim of this study was to evaluate the efficacy of some native plants, alone and in combination with some antibiotics, in the treatment of brucellosis.
methodsThe present experimental in vitro study was carried out to evaluate the anti-brucella activities of essential oils of Rosmarinus officinalis L., Origanum syriacum, Thymus syriacus, Salvia palaestina Benth, Mentha piperia, and Lavandula stoechas L., alone and in combination with some antibiotics. The activity against 16 tetracycline-resistant B. melitensis isolates was determined by disc diffusion method incorporating a concentration of 5%. Antibiotic discs were also used as a control. Microdilution brucella broth susceptibility assay was used in order to determine the MICs of essential oils and five antibiotics.
resultsAmong all the herbs evaluated, only the essential oils of O. syriacum and T. syriacus plants demonstrated most effective anti-brucella activity, and were then chosen for MIC study. The minimal inhibitory concentrations (MIC50) of essential oils of O. syriacum and T. syriacus against tetracycline-resistant B. melitensis were 3.125 µl/ml and 6.25 µl/ml, respectively.
conclusionAmong the essential oils studied, those of O. syriacum and T. syriacus were most effective. Since a combination of levofloxacin and Thymus syriacus essential oil increased the efficacy of this antibiotic, O. syriacum and T. syriacus are recommended to be used as bactericidal agents against B. melitensis.
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Identifiers
23645957PMC3642944W2184280857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.