ArticleThe British journal of ophthalmology2013
In vivo high-frequency contrast-enhanced ultrasonography of choroidal melanoma in rabbits: imaging features and histopathologic correlations.
Article in The British journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Transscleral Photodynamic Therapy with a Chlorin e6 Photosensitizer in a Rabbit Experimental Model of an Intraocular Mass Lesion.Journal of lasers in medical sciences · 2025Article
- Ultrasound in ocular oncology: Technical advances, clinical applications, and limitations.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Animal Models of Uveal Melanoma.Annals of eye science · 2022Article
- Clinical utility, dose determination, and safety of ocular contrast-enhanced ultrasonography in horses: A pilot study.Veterinary ophthalmology · 2020Article
- Quantitative, noninvasive assessment of intra- and extraocular perfusion by contrast-enhanced ultrasonography and its clinical applicability in healthy dogs.Veterinary ophthalmology · 2019Article
- Establishment of human metastatic colorectal cancer model in rabbit liver: A pilot study.PloS one · 2017Article
- Animal Models of Uveal Melanoma: Methods, Applicability, and Limitations.BioMed research international · 2016Review
- Animal Eye Models for Uveal Melanoma.Ocular oncology and pathology · 2015Review
- Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model.Journal of ophthalmology · 2015Article
- Acoustic characterization of contrast-to-tissue ratio and axial resolution for dual-frequency contrast-specific acoustic angiography imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the use of in vivo imaging of rabbit model of choroidal melanoma using high-frequency contrast-enhanced ultrasound (HF-CE-US) with two-dimensional (2D) or three-dimensional (3D) modes and to correlate the sonographic findings with histopathologic characteristics.
methodsFive New Zealand white rabbits, which were immunosuppressed with daily cyclosporin A (CsA), were inoculated into their right eyes with aliquots of 1.5×10(6)/50 μl of 92.1 human uveal melanoma cells cultured in RPMI. At week 4, the tumour-bearing eyes were imaged using high-frequency ultrasound (HF-US) with microbubble contrast agent to determine the 2D tumour size and relative blood volume and by 3D mode to determine tumour volume. Histologic tumour burden was quantified in enucleated eyes by ImageJ software, and mean vascular density (MVD) was determined by counting vascular channels in periodic acid Schiff (PAS) without haematoxylin sections.
resultsUsing HF-CE-US, melanomas were visualised as relatively hyperechoic regions in the images. The correlation coefficients of sonographic size and volume compared with histologic area were 0.72 and 0.70, respectively. The sonographic tumour relative blood volume correlated with the histologic tumour vascularity (r(2)=0.92, p=0.04).
conclusionsThere is a positive correlation between in vivo sonographic tumour volume/size and histologic tumour size in our rabbit choroidal melanoma model. HF-CE-US corresponds to MVD and blood volume.
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